Opiate , blood-brain barrier transport

Q6 Loperamide hydrochloride is an opioid. The starting dose will be 4 mg, which can be reduced to 2 mg, three times a day for five days if necessary. Opioids act on // opiate receptors in the myenteric plexus of the intestine and may modulate acetylcholine release to reduce peristalsis. They trigger mucosal transport of ions and water out of the lumen and cause a reduction in secretion. The absorption of fluid and electrolytes is increased since the stool remains in the colon for a longer period. Loperamide does not produce sedation or other central effects associated with opiates, since it does not cross the blood-brain barrier. 

Banks WA, Kastin AJ (1990) Editorial Review Peptide transport systems for opiates across the blood-brain barrier. Am J Physiol 259 E1-E10. 

Glycoproteins Blood-brain barrier Hormones 0-Linked glycopeptides Opiates Transport Abbreviations... 

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