Ophthalmic therapeutics topical instillation

Topical instillation is the principal route of ophthalmic drug delivery in the horse. It is used in the treatment of adnexal diseases, such as blepharitis and mebomiaiutis, and diseases of the ocular surfaces, such as conjunctivitis, superficial keratitis and comeal ulceration. Depending upon their physicochemical formulation, some drugs traverse the intact conjimctival and comeal epithelial barrier. This results in therapeutic levels within the comeal stroma and anterior chamber, facilitating the topical treatment of comeal stromal... 

Descemet s membrane, reestablishing stromal deturges-cence. Conservative therapeutic measures may be instituted during this resolution period, including the use of topical 5% sodium chloride drops during the day and 5% sodium chloride ointment instilled into the conjunctival sac at bedtime. Broad-spectrum topical ophthalmic antibiotics may be instituted to protect the compromised cornea from secondary bacterial infection. 

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