Adnexal disease

Topical instillation is the principal route of ophthalmic drug delivery in the horse. It is used in the treatment of adnexal diseases, such as blepharitis and mebomiaiutis, and diseases of the ocular surfaces, such as conjunctivitis, superficial keratitis and comeal ulceration. Depending upon their physicochemical formulation, some drugs traverse the intact conjimctival and comeal epithelial barrier. This results in therapeutic levels within the comeal stroma and anterior chamber, facilitating the topical treatment of comeal stromal... 

This chapter provides practical imormation regarding common corneal conditions that may require treatment. By nature of its anatomic proximity to and integration with other ocular and adnexal strnctnres, corneal abnormalities may result from diseases primary to the eyelids, conjunctiva, lacrimal system, episclera, and other tissues. The details of these conditions are not emphasized in this chapter thus the reader should refer to other appropriate chapters for this imormation. 

Poljrvidone storage disease can easily be diagnosed by its histopathological features. Skin biopsy specimens show a variable number of characteristic blue-gray vacuolated cells around blood vessels and adnexal structures, and stain positively with mucicarmine, colloidal iron, and alkaline Congo red and negatively with periodic acid Schiff and Alcian blue. 

Parenterally administered dmgs are used to treat adnexal and retrobulbar diseases, such as... 

This route should be used in the treatment of adnexal and anterior segment disease. 

Vulvar Paget disease, primary adnexal carcinoma CK7+, CCDFP-15+, CEA+... 

Gaffey MJ, Mills SE, Boyd JG Aggressive papillary tumor of middle ear/temporal bone and adnexal papillary cystadenoma. Manifestations of von Hippel-Lindau disease. Am J Surg Pathol. 1254 18(12) 1254-1260. 

Gross cystic disease fluid protein 15 (GCDFP-15) Breast carcinoma Salivary gland tumors, skin adnexal tumors, apocrine tumors Apocrine cells... 

Pain or an acute abdomen should alert to complications due to hemorrhage, rupture, and torsion of the adnexal mass (Fig. 9.17) or caused by nongyne-cological pelvic diseases. 

---