Oncogene Function

Roy LM, Haccard O, Izumi T, Lattes BG, Lewellyn AL, Mailer JL 1996 Mos proto-oncogene function during oocyte maturation in Xenopus. Oncogene 12 2203-2211 Sagata N 1997 What does Mos do in oocytes and somatic cells Bioessays 19 13-21... 

A unifying theme of the role of oncogene function in cell transformation is that the expression of the proto-oncogenes is normally tightly... 

The antiapoptotic function of the Bcl-2 protein has been clearly shown experimentally. Its overexpression can prevent initiation of the apoptotic program in various cell types. The oncogenic function of Bcl-2 protein, observed in association with its overex-... 

Nechers, L.M. (1989) Antisense oligonucleotides as a tool for studying cell regulation mechanism of uptake and application to the study of oncogene function. In J.S.Cohen (ed.) Oligodeoxyribonucleotides Antisense Inhibitors of Gene Expression. Macmillan Press, London. 

Secondary metabolites of Streptomyces sp. inhibiting oncogenic functions 91YGK1062. 

Screening of Oncogene Function Inhibitors from Microbial Secondary Metabolites... 

An active oncogene encodes the protein product having specific activity to induce transformation. The oncogene products are located either in the cytoplasm or in the nucleus. The src, yes, abl, erb B, erb BZ, and ras products are located in the cytoplasm, while the fos, jun, myc, and myb products are found in the nucleus (Fig. 2). The oncogene functions are summarized in Table 1. 

For the expression of ras oncogene function, Ras must bind to GTP. In the metabolic pathway of GMP synthesis, IMP is converted to XMP by IMP dehydrogenase, and the XMP is converted to GMP by GMP synthetase. Oxanosine itself does not inhibit IMP dehydrogenase, but oxanosine 5 -monophosphate inhibits IMP dehydrogenase almost competitively with the substrate. Therefore, it is likely that... 

The present volume reflects these developments, and there is a growing emphasis on bioactive natural products. Articles in this volume include those on structure-activity relationships of highly sweet natural products, chemical constituents of cchinodenns, diterpenoids from Rabdosia and Eremophila sp., structural studies on saponins, marine sesquiterpene quinoncs and antimicrobial activity of amphibian venoms. The reviews on bioactive metabolites of Phomopsis, cardenolide detection by ELISA, xenocoumacins and bioactive dihydroisocoumarins, CD studies of carbohydrate-molybdate complexes, oncogene function inhibitors from microbial secondary metabolites and Gelsemium and Lupin alkaloids present frontier developments in several areas of natural product chemistry. It is hoped that the present volume, which contains articles by eminent authorities in each field, will be received with the same enthusiasm as the previous volumes of this series. 

Overall, the upregulated miRNAs with oncogenic function in caner could be considered oncogenic miRNAs, named as oncomirs. The downregulated miRNAs with tumor-suppressor function could be considered as tumor-suppressor miRNAs. We will discuss the most well-understood oncomirs and tumor-suppressor miRNAs in the following sections. 

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