Omeprazole, tumors

IU/1, and urinary amylase 2895 IU/1. There was no evidence of tumor, hypertriglyceridemia, or lithiasis. In addition to prednisone, she was taking amlodipine, bromazepam, and omeprazole, none of which have been reported to cause pancreatitis. A marked improvement was noted after prednisone withdrawal. 

Lifelong toxicological studies of high-dose omeprazole in rats revealed the development of endocrine tumors (carcinoids) in the stomach, and this led to the halt-... 

A 74-year-old woman with seronegative rheumatoid arthritis was given sulfasalazine followed by methotrexate, both of which were withdrawn because of adverse effects. She also took prednisone 10 mg/day. She developed acute abdominal pain and fever (38.7 C) with no chills. Her serum amylase was 269 IU/1, serum lipase 300 IU/1, and urinary amylase 2895 IU/1. There was no evidence of tumor, hypertriglyceridemia, or lithiasis. In addition to prednisone, she was taking amlodipine, bromazepam, and omeprazole, none of which have been reported to cause pancreatitis. A marked improvement was noted after prednisone withdrawal. 

A 31 year old Japanese man with recurrent duodenal ulcer was treated with famotidine, omeprazole, and lansoprazole at different times over 3 years. Gastroscopy showed a small carcinoid tumor in the upper cardia after 35 months. The lesion became larger while the patient was taking lansoprazole. 

The proton pump inhibitors are usually well tolerated however, potential adverse effects include headache, dizziness, somnolence, diarrhea, constipation, and nausea. The frequency of adverse events appears to be similar to that seen with the H2-receptor antagonists. Concern and controversy regarding the safety of therapy with a proton pump inhibitor are based on the proton pump inhibitor s ability to cause hypergastrinemia and gastric carcinoid tumors in rats. After nearly a decade of experience with the proton pump inhibitors, gastric carcinoid tumors have not been directly linked to omeprazole use in humans. ... 

Omeprazole (Prilosec) Inhibits H+/K+ ATPase (proton pump) of parietal cell. Thus, reduces acid secretion. Reflux esophagitis, hypersecretory states. Few side effects. Constipation. Causes gastric carcinoid tumors in rats after prolonged use. 

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