Oligosaccharides sialylated, determinants

The precise chemical nature of some of the ligands involved in selectin-ligand interactions has been determined. All three selectins bind sialylated and fucosy-lated oligosaccharides, and in particular all three bind sialyl-Lewis (Figure 47-12), a structure present on both glycoproteins and glycolipids. Whether this compound is the actual ligand involved in vivo is not estab-... 

Figure 14.2 Representative oligosaccharide structures found on mammalian glycoproteins and glycolipids. The complex oligosaccharides may be bi-, tri-, or tetra-antennary the branches may be more or less elongated with 1—>4 linked lactosamine units, and they may or may not be sialylated. The SLex, Lea, and Leb structures represent the different blood group determinants often present on lipids, and the elongated core 2 structure is a mucin-type glycosylation. Proteoglycans have a common core to which a variety of linear acidic polysaccharides are attached.

IV Syntheses of Oligosaccharides and Derivatives Corresponding to the Sialyl-Lewis (sLe ) and Sialyl-Lewis (sLe ) Determinants... 

The structures of sialylated oligosaccharides in the urine of patients with mucolipidosis I ° or II have been determined. 

The H-n.m.r. spectra of various carrageenan-derived oligosaccharides have been analysed by means of DQ COSY and H- C-correlated methods. H- and C-asagnments have been reported for sialylated oligosaccharide alditols related to mucins, and for the pentasaccharide of the genus-specitic epitope of Chlamydia lipopolysaccharide. The structure of the fully methylated alditol acetate of 16 has been determined solely on the basis of n.m.r. data. A natural abundance heteronuclear-multiple-quantum-coherence (HMQC) experiment has been iUustrated by use of trisaccharide Lewis glucal. The solid state n.m.r. spectra of A-acetylurea derivatives obtained by reaction of hyaluronic acid with isotopically-labelled carbodiimides have been recorded. ... 

---