Chlamydia, lipopolysaccharides

The H-n.m.r. spectra of various carrageenan-derived oligosaccharides have been analysed by means of DQ COSY and H- C-correlated methods. H- and C-asagnments have been reported for sialylated oligosaccharide alditols related to mucins, and for the pentasaccharide of the genus-specitic epitope of Chlamydia lipopolysaccharide. The structure of the fully methylated alditol acetate of 16 has been determined solely on the basis of n.m.r. data. A natural abundance heteronuclear-multiple-quantum-coherence (HMQC) experiment has been iUustrated by use of trisaccharide Lewis glucal. The solid state n.m.r. spectra of A-acetylurea derivatives obtained by reaction of hyaluronic acid with isotopically-labelled carbodiimides have been recorded. ... 

Heine, H., Muller-Loennies, S., Brade, L., Lindner, B., Brade, H. Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC. Eur J Biochem 270 (2003) 440-450. 

Logusch and co-workers105 further explored the capabilities of 3 mm NMR probe technology in a study of the enzymatic synthesis of a rodent metabolite the preemergence herbicide alachlor. Lipopolysaccharides from Chlamydia trachomatis serotype L2 were the subject of a study using a 2.5 mm Bruker micro-NMR probe reported by Rundt et al.106 This work represents the first complete structural characterization of a lipopolysaccharide from a Chlamydial sp. 

Hoffmeister, A., Rothenbacher, D., Wanner, P., Bode, G., Persson, K., Brenner, H., Hombach, V., and Koenig, W. 2000. Seropositivity to chlamydial lipopolysaccharide and Chlamydia pneumoniae, systemic inflammation and stable coronary artery disease Negative results of a case-control study. J. Am. Coll. Cardiol. 35, 112-118. 

Rund, S. Lindner, B. Bradb, H. Holst, O. Structural analysis of the lipopolysaccharide from Chlamydia trachomatis serotype L2. J. Biol. Chem. 1999, 274, 16819-16824. 

---