Oligosaccharides chemically synthesized

H. Paulsen, Advances in selective chemical syntheses of complex oligosaccharides, Angew. Chem. Int. Ed. Engl. 21 155 (1982). 

Rhizobial exopolysaccharides show a highly diverse pattern of differently pyru-vated structures (see Table 1), and are therefore attractive targets for chemical syntheses. Some examples using pyruvated glycosyl donors are presented here in order to further demonstrate the special features of these donors for the synthesis of complex rhizobial oligosaccharides. 

Covalent immobilization of chemically synthesized carbohydrates onto derivatized surfaces by Seeberger group, (a) Attachment of thiol containing carbohydrates to maleimide-functionalized glass slides (b) attachment of amine-terminated heparin oligosaccharides onto amine-reactive glass slides... 

By the early 1970s, the art of oligosaccharide synthesis had reached a remarkable level, so that chemical syntheses of practical amounts of various blood-group-related ohgosaccharides became feasible, including the Lewis determinants. In the context of the present article, a brief overview will be given of seminal contributions by the schools of Lemieux. Paulsen, Ogawa,2 8,269 Schmidt,... 

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