Oligosaccharide synthesis on polymer

Olefin formation, by reductive elimination of 3-hydroxysulfones, 72, 2 Olefins, hydroformylation of, 56, 1 Oligomerization of 1,3-dienes, 19, 2 Oligosaccharide synthesis on polymer support, 68, 2 Oppenauer oxidation, 6, 5 Organoboranes ... 

This chapter discusses recent examples of enzymic oligosaccharide synthesis on polymer supports. Examples include cases where water insoluble acceptor-polymers of improved accessibility are used with soluble enzymes, and cases where water-soluble acceptor-polymers are used with either insoluble or soluble enzymes. The methodology is useful for preparative-scale reactions and for the study of enzymic properties. 

In contrast to oligosaccharide synthesis on polymer supports, the use of polymers as protecting groups in carbohydrate chemistry appears to be a more promising proposition and should be given attention as a convenient alternative to the solution method. 

These results demonstrate that O-glycosyl trichloroacetimidate-based oligosaccharide synthesis on solid support may eventually become a valuable alternative to solution-phase synthesis because useful experience is available for the selection of the polymer support and choice of the linker system and the glycosyl donor. Further standardization of the building blocks and the protective group pattern will finally provide the yields and the anomeric control in order to successfully plan automated syntheses of oligosaccharides also in a combinatorial manner. 

Very recently, Ito and coworkers disclosed a a resin-aided capture-release strategy in conjunction with oligosaccharide synthesis on a polymer support (Scheme 16) [42]. Interest-... 

OLIGOSACCHARIDE SYNTHESIS ON SOLID, SOLUBLE POLYMER, AND TAG SUPPORTS... 

Wong and coworkers have investigated the enzymatic oligosaccharide synthesis on a thermoresponsive polymer support (Scheme 16.33). The copolymers of 7V-/-propyla-crylamide (NIPAm) and functionalized monomers are thermoresponsive and exhibit inverse temperature-dependent solubility in water they are soluble in cold water but become... 

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