Capture and release strategy

Scheme 7.108 Generation of a pyrimidine library through a capture and release strategy.

X., Schultz, P. G. (2002) Resin-capture and release strategy toward combinatorial libraries of 2,6,9-substituted purines. J Comb Chem 4, 183-186. (b) Ding, S., Gray, N. 

Traceless solid-phase synthesis of 2,6,9-trisubstituted purines from resin-bound 6-thiopurines <02T7911>, and microwave assisted solid-phase synthesis of 2,6,9-trisubstituted purines <02TL6169> have been described. A resin-capture and release strategy toward combinatorial libraries of 2,6,9-trisubstituted purines has been reported <02JCO183>. Alkylated purines chlorinated at the 6,8- or 2,6,8-positions can be captured onto a solid support and further elaborated by aromatic substitution or via palladium catalyzed crosscoupling reactions <02JA1594>. 

Another example of the capture and release strategy, use of polystyrene-bound piperazine for generation of a pyrimidine library, was recently reported [121]. In a... 

Trisubstituted Purines. Schultz and Brun have reported a traceless resin capture and release strategy for the solid-phase synthesis of 2,6,9-trisubstituted purines... 

Amination of azaheteroaryl bromides and chlorides has also been reported to be smoothly executed within 10 min by use of standard reaction conditions and microwave irradiation [118]. Benzimidazoles have been prepared by Brain and Steer via intramolecular cyclization using an amidine moiety as the N-nucleophile [119]. The reaction was rapid and high yielding, and in combination with a catch and release strategy featuring capture of the benzimidazole on an acidic resin in the... 

Scheme 2. The indole core structure is present in natural products and drugs, like for example Indomethacine and can therefore be considered as a privileged structure. A resin-capture-release strategy to synthesize an indole based compound library has been developed by Waldmann and co-workers.

Very recently, Ito and coworkers disclosed a a resin-aided capture-release strategy in conjunction with oligosaccharide synthesis on a polymer support (Scheme 16) [42]. Interest-... 

S. Hanashima, S. Manabe, and Y. Ito, Divergent synthesis of sialylated glycan chains Combined use of polymer support, resin capture-release, and chemoenzymatic strategies, Angew Chem. Int. Ed., 44 (2005) 4218 1228. 

An elegant and efficient label-free method of enrichment of HNE-modified peptides by SPH chemistry utilizes reversible hydrazide chemistry to selectively capture and then release HNE-modified peptides from within complex mixtures [5], as shown in Scheme 2.2. In this strategy, HNE-modified peptides are captured on hydrazide-coated glass beads via the formation of covalent hydrazone linkage between the hydrazide group immobilized on the solid support and the aldehyde group in the modified peptides facilitating their selective enrichment. The hydrazone bond is acid labile and, hence, the modified peptides can be easily recovered from the SPH beads under acidic conditions. 

Functionalization of POFs via the PSM strategy enhances the binding capacity to small molecules e.g., hydrogen and methane in clean energy stor-age, and carbon dioxide in carbon capture and sequestration), improves the catalytic activity and selectivily and promotes drug delivery and release. 

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