Oligosaccharide medicinal chemistry

Ogura H, Hasegawa A, Suami T (eds) (1992) Carbohydrates. Synthetic methods and applications in medicinal chemistry. VCH and Kodansha, Weinheim and Tokyo Kovac P (ed) (1994) Synthetic oligosaccharides. Indispensable probes for the life sciences. ACS Symposium Series 560. American Chemical Society, Washington Whitfield DM, Douglas SP (1996) Glycoconjugate J 13 5... 

An important aspect of this approach is the ease with which fiiran alcohols can be prepared in enantiomerically pure form from achiral furans (e.g., 7 and 8). There are many asymmetric approaches to prepare furan alcohols. The two most prevalent approaches are (i) the Noyori reduction ofacylfurans (8 to 12) and (ii) the Sharpless dihydroxylation of vinyUurans (7 to 12) (Scheme 1.4) [17]. Both routes are readily adapted to 100 g scale synthesis and use readily available reagents. While the Sharpless route is most amenable to the synthesis of hexoses with a C-6 hydroxy group, the Noyori route distinguishes itself in its flexibility to virtually any substitution at the C-6 position. Herein, we review the development of the Achmatowicz approach to the de novo synthesis of carbohydrates, with apphcation to oligosaccharide assembly and medicinal chemistry studies. 

THE CHEMISTRY OF OLIGOSACCHARIDE LIGANDS OF SELECTINS SIGNIFICANCE FOR THE DEVELOPMENT OF NEW IMMUNOMODULATORY MEDICINES ... 

Enzymatic process is the main method to produce cyclodextrins (CDs), and so far, chemical methods have been reported. CD is industrially produced from starch, glucogen, malto-oligosaccharides, and other dextrins through catalysis by cyclodextrin glucosyl transferase (CGTase). More and more researchers focus on the essential CGTase to prepare CD due to its wide applications in food, medicine, cosmetics, environmental protection, and analytical chemistry. 

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