Oligosaccharides ligand

Fig. 40. Simple lactoside analogues as surrogates for the more complex GML oligosaccharide ligand against the pentameric bacterial toxin from Vibrio cholerae 09...

TABLE 7-3 Some Lectins and the Oligosaccharide Ligands They Bind... 

M. Terada, K.-H. Khoo, R. Inoue, C.-I. Chen, K. Yamada, H. Sakaguchi, N. Kadowaki, B. Y. Ma, S. Oka, T. Kawasaki, and N. Kawasaki, Characterization of oligosaccharide ligands expressed on SW1116 cells recognized by mannan-binding protein, J. Biol. Chem., 280 (2005) 10897-10913. 

Nelson, R M, Dolich, S, Aruffo, A, Cecconi, O, Bevilacqua, M P, Higher-affinity oligosaccharide ligands for E-selectin, J. Clin. Invest., 91, 1157-1166, 1993. 

The sulfated monosaccharides have been gaining prominence recently as they seem to play a well documented role as the critical components of the oligosaccharide ligands for the selectins. The structural and biochemical progress in this area is very fast with both the contribution from chemical synthesis and enzymology of the specific sulfotransferases [238]. 

L-Fucose occurs either at terminal or preterminal positions of many cell surface oligosaccharide ligands. These fucosylated oligosaccharides mediate cell-cell recognition and adhesion-signaling pathways. Some of these processes... 

Finally, we recall that oligosaccharide ligands are not systematically nonreducing terminal sequences. We have mentioned the conformational epitope of an a- 2—>8) sialic acid in Section 12.5.2. Another very well known example is the heparin pentasaccharide (Section 17.3.4). In this case we note that a succession of metabolic transformations has greatly altered a five-sugar sequence in a monotonous polysaccharide chain. 

THE CHEMISTRY OF OLIGOSACCHARIDE LIGANDS OF SELECTINS SIGNIFICANCE FOR THE DEVELOPMENT OF NEW IMMUNOMODULATORY MEDICINES ... 

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