Oligonucleotides Containing Modified

2 Oligonucleotides containing modified sugars - A method has been reported for 

Benzophenone-mediated sensitisation of d(TpG) irradiated at 350 lun in an oxygen-saturated aqueous solution produces thymidylyl(3 -5 )-2 -deoxy-D-ribono-1,4-lactone d(TpL)  

An CK-anomeric oligoribonucleotide a- r(UCUU AACCCACA)] has been synthesised using 125 

Conformational analysis of oligonucleotide single strands containing 2, 3 -dideoxygluco-pyranosyl building blocks (162), (the so-called homo-DNA) has been used to address the question as to why nature chose pentose, rather than hexose sugar units for the construction of 128 

The oligomers were prepared by a phosphotriester approach using synthons with the general 132 

---

Compagno, D., Lampe, J.N., Bourget, C., Kutyavin, I.V., Yurchenko, L., Lukhtanov, E.A. and Gom, V.V. (1999) Antisense oligonucleotides containing modified bases inhibit translation of Leishmania amazonensis mRNAs by invading the mini-exon hairpin. J. Biol. Chem., 274, 8191-8198. 

A Oligonucleotides Containing Modified Sugars. a-Anomeric oligoribonucleo-tldes a-rlls and a-rllu have been prepared on a solid-phase support from... 

Oligonucleotides containing modified phoqibodiester linkages - Activity in... 

The ability to synthesise oligonucleotides containing modified phosphodiester linkages continues to be of great interest in the therapeutic area. In particular it is desirable to confer through these modifications enhanced cell permeability properties and nuclease resistance. Several previous candidates that confer these properties have modified the pho,sphodiester linkage in such a way that creates a chiral centre at phosphorus. The resultant complex mixture of diastereoisomers all meet the above requirements to different extents, Over the past year efforts have therefore concentrated on the synthesis of achiral alternative linkages or stereospecific syntheses of chiral phosphate modifications. A number of literature summaries in this area have appeared recently. 

---