Weight gain olanzapine

Gupta S, Droney T, Al-Samarrai S, Keller P, Frank B. Olanzapine weight gain therapeutic efficacy. J Clin Psychopharmacol 1999 19(3) 273-5. 

Olanzapine/weight gain CYP2D6 11 Association SEDA-27, 61... 

Olanzapine/weight gain 5-HT2C receptors ( 759C7r) 42 Possible protective effect of the T allele SEDA-30, 66... 

Olanzapine/weight gain ADRA2A (-129100) 62 G allele associated with a higher risk SEDA-31, 85... 

Olanzapine/weight gain Apohpoproteins E and A4 and scavenger receptor class B, member 1 67 Weight profiles significantly associated SEDA-32,103... 

Olanzapine/weight gain LEP- and LEPR 200 LEPR Q223R polymorphism may be associated with obesity in women with a psychotic disorder treated with atypical antipsychotic drugs [471... 

Clozapine and olanzapine Increase Unclear weight gain... 

Nevertheless, some atypical antipsychotic drugs, such as clozapine and olanzapine, have been linked to substantial weight gain, hyperlipidemia and type II diabetes, a new range of medically serious side-effects. 

Quetiapine (Seroquel). Another atypical antipsychotic, quetiapine has also been approved by the FDA for the treatment of acute mania. It is usually administered twice daily at doses of 150-750mg/day. Like its counterparts, quetiapine is a well-tolerated medication. Its common side effects are drowsiness, dizziness, and headache. It causes less weight gain than olanzapine or clozapine but more than ziprasidone or aripiprazole. Quetiapine also does not cause agranulocytosis nor does it increase the risk of seizures. It can occasionally cause mild changes in liver function tests, but these usually return to normal even if the patient continues taking quetiapine. 

Despite the widespread use of neuroleptics in maintenance treatment of bipolar disorder, there have not been any systematic studies of their suitability for this role. Through clinical experience it has been widely accepted that neuroleptics are useful adjunctive treatments to lithium and related drugs. Treatment refractory patients frequently respond to atypical antipsychotics such as clozapine or risperidone. Such adverse effects as EPS, cognitive dysfunction and weight gain frequently limit the long-term use of classical neuroleptics. For this reason, the atypical neuroleptics such as olanzapine and risperidone should now be considered as alternatives for maintenance treatment. 

All antipsychotics except clozapine and perhaps olanzapine produce hyperprolactinemia by removing the inhibitory actions of dopamine on prolactin secretion. This results in amenorrhea, galactorrhea, and infertility in women and in loss of libido and impotence in men. Inhibition of the release of follicle-stimulating and luteinizing hormones may also play a role. In addition, weight gain is common, and food intake must be monitored. 

Olanzapine. An open trial of olanzapine monotherapy in youths with BPD showed that treatment improved mania, psychosis, depression, and aggression (Frazier et ah, 2001). Olanzapine was well tolerated and medication compliance was excellent. Weight gain was the most significant side effect (mean weight gain of 5 2.3 kg). 

Olanzapine Moderate weight gain, somnolence 10-15 5 mg/day increments 5-20... 

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