Of water ammonia mixture with

TABLE 4. Measured and Correlated pH of Water-Ammonia Mixtures with no Acid Gas Present, 25°C... 

The requisite intermediate. 10-(3-chloropropyl)-2-acety(phenothiazine is prepared as follows To a suspension of sodamide (from 3 grams of sodium) in 300 ml of liquid ammonia is added 30 grams of 2-acetylphenothiazine. After stirring for one hour, there is added 19 grams of 1-bromo-3-chloropropane. The ammonia is allowed to evaporate and the residue is diluted with 200 ml of water. The mixture is extracted with ether and the ether solution is dried over anhydrous sodium sulfate, filtered and concentrated. 

In about 250 cc of liquid ammonia (cooled with dry ice and acetone) are dissolved about 7.5 g of potassium and into the solution acetylene is passed until the blue color has disappeared (about 3 hours). Then slowly a solution or suspension of 3 g of estrone in 150 cc of benzene and 50 cc of ether is added. The freezing mixture is removed, the whole allowed to stand for about 2 hours and the solution further stirred overnight. Thereupon the reaction solution is treated with ice and water, acidified with sulfuric acid to an acid reaction to Congo red and the solution extracted five times with ether. The combined ether extracts are washed twice with water, once with 5% sodium carbonate solution and again with water until the washing water is neutral. Then the ether is evaporated, the residue dissolved in a little methanol and diluted with water. The separated product is recrystallized from aqueous methanol. The yield amounts to 2.77 g. The 17-ethiny I-estradiol-3,17 thus obtained melts at 142°C to 144°C . 

Thebaine is dissolved in aqueous formic acid and treated with 30% HjO neutralization with aqueous ammonia gives 14-hydroxycodeinone. It is hydrogenated to give oxycodone. 90 ml of concentrated hydrobromic acid are heated to 90°C. 9 grams of 14-hydroxydi-hydrocodeinone (oxycodone) are then added under stirring and the mixture is quickly heated to 116°C and kept at this temperature under reflux condenser for 20 minutes, with continued stirring. The resulting brown solution Is diluted with about 90 ml of water and chilled with ice. Aqueous 10% sodium hydroxide solution is now added to alkaline reaction and the liquid is extracted 3 times with 100 cc portions of chloroform. The layers are separated and the aqueous phase is fiitered and acidified by the addition of concentrated aqueous hydrochloric acid, treated with charcoal and filtered. 

A solution of 2.25 g (25 mmol) of D-glyccraldehyde in 300 mL of water is combined with a solution of 20 mmol of dihydroxyacetonc phosphate (DIIAP) in 200 mL of water freshly adjusted to pH 6.8. The mixture is incubated with 100 U of L-rhamnulose 1-phosphate aldolase at r.t. for 24 h with monitoring of conversion by TLC (2-propanol/sat. ammonia/water 6 4 2) and by enzymatic assay for DHAP55. 

TABLE 15. Measured and Correlated Ammonia Mixtures with 0. Mole of NH3> 80°C pH of Water-258 Mole of H2S/ ... 

In the presence of water, iodine reacts with ammonia to give explosive NI3 as a black precipitate. In anhydrous liquid ammonia at -33 C (or at lower temperatures) practically no conversion takes place, however. This appears most convincingly from the fact that aryl- or heteroaryl iodoacetylenes can be prepared in excellent yields by seining a mixture of equimolar amounts of iodine and the acetylene in liquid ammonia for several hours [121]. For the less... 

One of the most economical of these processes is that proposed hy Messrs. Hemming and Dyer, which is founded on the behavior of a solution of common salt with one of bicarbonate of ammonia. When carbonate of ammonia of commerce, which is in reality a mixture of carbonate and bicarbonate, is added in a etate of lino powder to a solution of about an equal weight of salt in throe parts of water, tho mixture being well stirred, a white crystalline precipitate appears in a few hours, causing the liquid to become thick. This precipitate is bicarbonate of soda, and there is contained in solution chloride of ammonium, produoed as shown in the annexed equation-... 

C) dl-Isoleucine.—One hundred and fifty grams (0.77 mole) of a-bromo-/3-methyl valeric acid is added to 645 cc. of technical ammonium hydroxide (sp. gr. 0.90) in a 1.5-I. round-bottomed flask. A stopper is wired in and the flask allowed to stand at room temperature for a week (Note 9). The stopper is removed and the mixture heated on a steam cone overnight to remove ammonia. The aqueous solution is concentrated under reduced pressure until bumping becomes violent (about 300 cc.). The mixture is then cooled to 150 and the crystals collected on a filter. The crystals are washed with 40 cc. of alcohol and dried. The filtrate is again concentrated to about 150 cc. and a second crop of crystals obtained. This second crop is washed with 25 cc. of water and then with 25 cc. of 95 per cent alcohol. The yield of crude product is 65 g. 

One hundred grams of ammonium chloride and 135g of sodium nitrite are dissolved in 780ml of water and mixed with a solution of 90g of cobalt (II) chloride 6-hydrate in 280ml of water Then 28ml of concentrated ammonia are added mid the entire mixture is aerated vigorously for 1% hours in a 2-Hter filter fiaak fitted with a stopper and a gas inlet tube. 

Treatment of 3-chloro-6-phenyl-l,2,4-triazine A with 1.1 equivalents of phenylacetonitrile in dry N.N-dimethylacetamide at 0°C in the presence of an excess of KOlBu for one hour followed by quenching of the reaction mixture with ice-water gave an 86% yield of a dinitrile B, C17H12N4. Treatment of B with 1 1 aqueous ammonia/acetone for one hour resulted in quantitative conversion into 3-amino-4,6-diphenylpyridazine, C. The triazine A was converted directly into the pyridazine C when DMF was used as solvent and the reaction mixture was quenched with aqueous acetic acid. 

Five grams (0.0135 mol) of tris(biguanido) chromium (III) 1-hydrate is dissolved in 200 ml. of water and treated with a solution of 5,7 g. (0.043 mol) of ammonium sulfate in 10 ml. of water. The sparingly soluble tris(biguanide)-chromium sulfate is precipitated with liberation of ammonia. The mixture is heated on the water bath, whereby... 

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