Of postpartum hemorrhag

Ergonovine (100, R = NHCH(CH3)CH2 0H) was found to yield lysergic acid (100, R = OH) and (+)-2-aminopropanol on alkaline hydrolysis during the early analysis of its stmcture (66) and these two components can be recombined to regenerate the alkaloid. Salts of ergonovine with, for example, malic acid are apparently the dmgs of choice in the control and treatment of postpartum hemorrhage. 

Ergonovine and metiiylergonovine may be given orally during die postpartum period to reduce die possibility of postpartum hemorrhage and to prevent relaxation of die uterus. When die patient is to receive eitiier of tiiese drains after delivery, it is important to take die blood pressure, pulse, and respiratory rate before administration. 

Misoprostol may also prove useful in the treatment of postpartum hemorrhage and has also been used in organ transplantation. For example, it has been reported to improve kidney function in cyclosporin-treated patients who have received renal transplants (334). 

The uterus of a nonpregnant woman usually is mildly stimulated by meperidine. Administered before an oxytocic, meperidine does not exert any antagonistic effect. Therapeutic doses given during active labor do not delay the birth process in fact, the frequency, duration, and amplitude of uterine contraction sometimes may be increased. The drug does not interfere with normal postpartum contraction or involuntary contraction of the uterus, and it does not increase the incidence of postpartum hemorrhage. 

Hydrastine, which occurs along with berberine and canadine in Hydrastis canadensis L. (golden-seal), is closely related to the minor opium alkaloit narcotine. At one time, it found hmited use as a bitter stomachic, and was employed in catarrhal conditions because of a rather obscure action on mucous membranes. It exerts a stimulant action on the uterus and has been advocated for the management of postpartum hemorrhage. It has been dropped, however, from the United States Pharmaco-... 

Unlike warfarin, heparin is safe for anticoagulant therapy during pregnancy (134). Although warfarin is known to cause serious fetal malformations when used in pregnancy, heparin does not cross the placental barrier and has shown no tendency to induce fetal damage. Furthermore, heparin does not increase fetal mortality or prematurity. To minimize the risk of postpartum hemorrhage, it is recommended that heparin therapy be withdrawn 24 hours before delivery. 

Significant side effects are those associated with its abortifacient properties and other smooth muscle contraction effects, e.g., diarrhea and abdominal pain. Misoprostol also is an effective cervical ripening agent (by vaginal application) for the induction of labor. Other unlabeled uses include the treatment of postpartum hemorrhage and, with mifepristone, termination of pregnancy. 

Ergonovine is a water-soluble lysergic acid derivative that occurs in ergot. It is used as an oxytocic agent. Its maleate derivative is used in the treatment of postpartum hemorrhage. 

This compound is a homologue of ergonovine. It is used in the treatment of postpartum hemorrhage. 

Jackson KW Jr, Allbert JR, Schemmer GK, Elliot M, Humphrey A, Taylor J (2001) A randomized controlled trial comparing oxytocin administration before and after placental delivery in the prevention of postpartum hemorrhage. Am J Obstet Gynecol 185 873-877... 

Yamashita Y, Takahashi M, Ito M, Okamura H (1991) Transcatheter arterial embolization in the management of postpartum hemorrhage due to genital tract injury. 

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