Of Grignard reagents, and

Secondary alcohols may be prepared by two different combinations of Grignard reagent and aldehyde... 

Three combinations of Grignard reagent and ketone give rise to tertiary alcohols... 

Addition of Grignard reagents and organolithium compounds (Sections 14 6-14 7) Aldehydes are converted to secondary alcohols and ketones to tertiary alcohols... 

Addition of Grignard reagents and organolithium compounds to the pyridazine ring proceeds as a nucleophilic attack at one of the electron-deficient positions to give initially... 

Secondary aziridines bearing a trifluoromethyl group were prepared via the Hoch-Campbell reaction of Grignard reagents and oximes bearing a trifluoromethyl... 

The Addition of Grignard Reagents and Organolithium Reagents to Aldehydes and Ketones... 

STEP 3. The last or organodealkoxylation step can no doubt be carried out with a variety of Grignard reagents, and thus it is clearly flexible too. From the results of various experiments, it is apparent that framework retention in this step is aided by a low temperature (-0 °C) and a moderate Grignard reagent to alkoxy group ratio (-2 1). 

The most important reactions of Grignard reagents and organolithium compounds are the nucleophilic attack to the carbonyl group. 

Early attempts to convert aliphatic nitriles into primary cyclopropylamines, in the same way as N,N-dialkylcarboxamides 44 are transformed to N,N-dialkylcyclopropylamines 47 under the action of Grignard reagents and Ti(OiPr)4, were unfruitful [136], However, Szymoniak et al. have found that the addition of a Lewis acid such as boron trifluoride etherate is necessary to activate azatitanacyclopentene 153 resulting from insertion of... 

MgBr2-mediated asymmetric nucleophilic addition of Grignard reagents and allyl-tributyltin to aldehydes bearing sugar-derived jS- or y-tetrahydropyranyloxy chiral auxiliaries designed to complex with MgBt2 has been achieved. ... 

Aryl and alkyl organozincate reagents, generated in situ by reaction of Grignard reagents and sub-stoichiometric amounts of ZnCl2, cross-couple smoothly in refluxing THF with functionalized aryl and alkenyl as well as primary and secondary alkyl chlorides in the presence of Pd(dppf)Cl2. ... 

The SET mechanism is known to be operative for reactions of Grignard reagents and aromatic ketones such as benzophenone ". In reactions of Grignard reagents and aliphatic ketones and aldehydes, the polar mechanism seems to be major . The reactions of aliphatic ketones and aldehydes are more widely ntilized in organic syntheses. Thns, at first, the polar addition mechanism was examined. 

Problem 14.31 (a) Give the product of the S 2-type addition of CjHjMgBr to ethylene oxide, (b) What is the synthetic utility of the reaction of Grignard reagents and ethylene oxide 4... 

The reactions here described are of considerable general utility for the preparation of a variety of fatty acids from the addition products of Grignard reagents and ./3-unsaturated esters.4-9... 

As exemplified in the sections indicated, these compounds show most of the typical reactions of Grignard reagents and alkyllithiums. Thus, pyridyllithiums and their benzo analogues allow the introduction of other metals, and non-metals, on to the ring, such as mercury, boron, phosphorus, tin and arsenic (Scheme 74) (see also Section 3.2.3.10.2.v). 

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