OATP SLCO Family Transporters

Transporter Gene symbol Chromosome Reference accession (m RN A) Amino acids Transmembrane domains Tissue distribution Cellular localization Substrates 

OATP2B1 SLC02B1 llql3 NM 007256 709 12 Liver, intestine, and so on Basal (liver), apical (intestine) E-sul, DHEAS, pravastatin, rosuvastatin, glybenclamide, benzylpenicillin, and so on 

NTCP SLC10A1 14q24 NM 003049 348 7 Liver Basal Bile acids, DHEAS, BSP, and E-sul 

OAT2 SLC22A7 6p21 NM 006672, NM 153320 546/548 12 Liver Basal a-Ketoglutarate, salicylate, methotrexate, zidovudine, 5-fluorouracil, and so on 

OCT1 SLC22A1 6q26 NM 003057, NM 153187 554/506 12 Liver, kidney Basal TEA, TBuMA, MPP, acyclovir, ganciclovir, famotidine, metformin, and so on 

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Organic Anion Transporting Polypeptide (OATP/SLCO) Family... 

Hagenbuch, B. and Meier, P.J. (2004) Organic anion transporting polypeptides ofthe OATP/SLC21 family phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. 

OATP/SLCO superfamily is classified into six families in mammalians (64). This chapter described the characteristics of three families (OATP1, OATP2, and OATP4), which have been suggested to be involved in the drug disposition, i.e., hepatic uptake process, basolateral uptake and reabsorption in the kidney, intestinal uptake, and efflux transport in the barriers of central nervous system. 

Oatps/OATPs are multispecific sodium-independent transport proteins. They comprise at least 36 members of human, rat, mouse, and some nonmammalian species. On the basis of their phylogenetic relationships, all rodent and human Oatps/OATPs so far identified within the OATP/SLCO superfamily of solute carriers have been classified into 6 families and 13 subfamilies (Figure 3.1) 2]. 

Hagenbueh B and Meier PJ (2004) Organie anion transporting polypeptides of the OATP/ SLC21 family phylogenetie elassifieation as OATP/ SLCO superfamily, new nomenelature and molecular/funetional properties. Pflugers Archiv 447 653-665. 

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