O-isobutyl S-

Type Chemical name B - persistent O-isobutyl S-(2-diethylaminoethyl)methyl phosphothioate... 

Chang, F.C.T., Hoffman, B.E., DeBus, S. (2002). Pharmacological antagonism of lethal effects induced by O-isobutyl S-2-(dieth-ylamino)ethyl]-methylphosphonothioate. Drug Chem. Toxicol. 25 321-37. 

Maxwell DM, Brecht KM and Koplovitz I (1997). Characterization and treatment of the toxicity of O -isobutyl S-[2-(diethylamino) ethyljmethylphosphonothioate, a structural isomer of VX, in guinea pigs. J Am Coll Toxicol, 15 (Supplement 2), S78-S88. 

Figure 6. El and Methane Cl Mass Spectra of the O-Isobutyl S-dimethylaminoethyl methylphosphonothiolate (S-5)...

Fig. 2. Relation (8b) between the activity of ZSM-5 and AAS in isobutyl alcohol dehydration to butene at 3971C and the number of (a) Brensted acid sites [B] (b) strong Lewis acid sites, [LL , and (c) weak Lewis acid sites, [L]weak. (A) NaHZSM-5 sample 2 (9) HZSM-5, sample I (O) HZSM-S, sample 3 ( ) HZSM-5, sample 4 ( ) amorphous aluminosilicate, AAS.

Enna S. J (1981) GABA receptor pharmacology, functional considerations. Biochem Pharmacol. 30, 907-913 Felker P. (1978) Gas-hqmd chromatography of the heptafluorobutyric-O-isobutyl esters of ammo acids. J Chromatogr 153, 259-262 Fonnum F (1981) The Turnover of Transmitter Ammo Acids, With Special Reference to GABA, in Central Neurotransmitter Turnover (Pycock C J. and Tabener P V, eds.) University Press, Baltimore, pp 105-124... 

Oxaziridines substituted in the 2-position with primary or secondary alkyl groups undergo decomposition at room temperature. In the course of some weeks, slow decomposition of undiluted compounds occurs, the pattern of which is analogous to that of acidic or alkaline N—O cleavage (Sections 5.08.3.1.3 and 4), Radical attack on a C—H bond in (109) effects N—O cleavage, probably synchronously (57JA5739). In the example presented here, methyl isobutyl ketone and ammonia were isolated after two hour s heating at 150 °C. 

Obviously, accurate concentrations of other gases or vapors cannot be indicated unless the instrument has been appropriately calibrated for each of these gases. Furthermore, the manufacturer s calibration may not be sufficiently accurate and a correction may be required. For example, a meter reading of 2.0 on the 0 to 10% LEL scale of one instrument would indicate, for a solvent having an LEL of 1.4 %, a concentration of 280 ppm (0.02 x 14,000 ppm). Benzene, methyl isobutyl ketone (MIBK). For example, a meter reading of 2.0 on the O-to-10% LEL scale of one instrument would indicate, for a solvent having an LEL of 1.4%, a concentration of 280 ppm (0.02 x 14,000 ppm). Benzene, methyl isobutyl ketone (MIBK) and toluene all have LEL s of 1.4%, but actual concentrations at a meter... 

The dibromoalkene S-40 can be prepared from S-ethyl lactate by introduction of the MEM (methoxyethoxymethyl) protecting group, reduction to the O-protected lactaldehyde and Corey-Fuchs carbonyl olefination (Scheme 19). The l -enantiomer of 40 is available analogously from f -isobutyl lactate and serves as the reagent in the enantiomeric series. The lithium carbenoid S-41 is generated from S-40 by treatment with n-butyllithium in diethyl ether and reacted with aliphatic and aromatic aldehydes in tetrahydrofuran. High diastereoselectivities are reached, as shown in Scheme 19 . ... 

A second, more versatile, method involves the O-acyl thiohydroxamates. These compounds are generally prepared by reaction of acyl chlorides with the commercial sodium salt (1) of 2-mercapto-pyridine A(-oxide (equation 6 X = Cl). Use of mixed anhydrides formed by reaction of the carboxylic acid with isobutyl chloroformate (equation 6 X = OCC>2CH2CHMe2) renders the procedure compatible with unprotected indoles, phenols, secondary and, presumably, tertiary alcohols. An alternative mode of preparation of the 0-acyl thlohydroxamates involves the s t (2) in reaction with the carboxylic acid (equation 7). 

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