Null false rejection

If the null hypothesis can be rejected on the basis of a 95% confidence test, then the risk of falsely rejecting the null hypothesis is at most 0.05, but might be much less. We don t know how much less it is unless we look up the critical value for, say. 

Similarly, if the null hypothesis cannot be rejected at the 95% level of confidence it does not mean that the quantity being tested is insignificant. Perhaps the null hypothesis could have been rejected at the 90% level of confidence. The quantity would still be rather significant, with a risk somewhere between 0.05 and 0.10 of having falsely rejected the null hypothesis. 

The relationship between the risk, a, of falsely rejecting the null hypothesis and the level of confidence, P, placed in the alternative hypothesis is P = 100(1 - a)%. If the null hypothesis is rejected at the 87% level of confidence, what is the risk that the null hypothesis was rejected falsely ... 

Based on the sample data, we may reject the null hypothesis when in fact it is true, and consequently accept the alternative hypothesis. By failing to recognize a true state and rejecting it in favor of a false state, we will make a decision error called a false rejection decision error. It is also called a false positive error, or in statistical terms, Type I decision error. The measure of the size of this error or the probability is named alpha (a). The probability of making a correct decision (accepting the null hypothesis when it is true) is then equal to 1—a. For environmental projects, a is usually selected in the range of 0.05-0.20. 

Suppose that the true mean concentration p is llOmg/kg, but the sample mean concentration is 90mg/kg. In this case, the null hypothesis is true (H0 llOmg/kg > lOOmg/kg). However, basing our decision on the sample data, we reject it in favor of the alternative hypothesis (Ha 90mg/kg< lOOmg/kg) and make a false rejection decision error. 

Control of the FDR, controls the expected proportion of true null hypotheses rejected among all the hypotheses rejected. In the gene expressions setting, the FDR is the expected proportion of false positives among those inferred to be differentially expressed. 

As suggested above it is customary to work at the 95 percent or sometimes at the 99 percent probability level. The 95 percent probability level, which gives a 5 percent chance of a Type I error, represents the usual optimum for minimizing the two types of statistical error. A Type I error is a false rejection by a statistical test of the null hypothesis when it is true. Conversely, a Type II error is a false acceptance of the null hypothesis by a statistical test. The probability level at which statistical decisions are made will obviously depend on which type of error is more important. 

Here all entries in the table are frequencies. We suppose that m null hypotheses are being tested. U, V, T and S are unobservable random variables, whereas R is an observable random variable. That is to say, we can see how many h3fpotheses we reject, and this is R but we don t know how many are false, which is S. If V true hypotheses are rejected then what Benjamin and Hochberg refer to as the per comparison error rate (PCER) is [y/m], which is to say that it is the expected proportion of all hypotheses tested that are falsely rejected. 

Now, suppose all null hypotheses are true, so that Mq = m, then m — Wq = 0 and therefore 5=0 and testing each hypothesis at level a will give E [V jm = a. In general, if there are some false null hypotheses, then the expected value of V will be less but the value of m will be unchanged so that the E [V jm < a. Thus the PCER is controlled at or below a by this strategy. On the other hand, the family-wise error rate (FWER) is simply the probability that at least one hypothesis is falsely rejected, and this is P (V > 1). This... 

Before choosing the critical value, one specifies one s tolerance for Type I errors, defined as erroneous rejection of the null hypothesis when it is true. Type I errors are sometimes called/fltoe positives or false rejections. Regardless of the choice of the critical value, there is always the probability of a Type I error. For large enough critical values, this probability is small and generally can be tolerated. The tolerable probability that one specifies is called the significance level of the test and is usually denoted by a. In radioanalytical chemistry, it is common to set a = 0.05. If O = 0.05, then analyte-free samples should produce false positive results at a rate of only about one per twenty measurements. 

The significance level represents the probability that the null hypothesis is falsely rejected. 

The alpha level or Type I error rate-. By convention, the level of alpha is usually set at. 05, but this figure is arbitrary. The Type I error rate is the probability of falsely rejecting the null hypothesis that is, the chance of concluding that a systematic relationship exists in the population when it, in fact, does not. This possibility tends to predominate the consciousness of investigators and many post-hoc techniques (e.g., the Bonferoni inequality, the Newman-Keuls test, etc.) have been developed to control it. 

The probability of falsely rejecting the null hypothesis (i.e., the chance of concluding that a systematic relationship exists in the population when it does not)... 

The second type of error occurs when the null hypothesis is retained even though it is false and should be rejected. This is known as a type 2 error, and its probability of occurrence is [3. Unfortunately, in most cases [3 cannot be easily calculated or estimated. 

The simultaneous test given by Equations 6 and 7 leads to a test appropriate for (X,t) unknown. The (X,T)-unknown test rejects the null hypothesis that xgj belongs to the background population if tj > c(r) for all (X,t). Since this test rejects the null hypothesis only if Equation 6 is satisfied for the true value of (X,t), this test has no greater probability of false detection than the simultaneous test. Thus, the (X,r)-unknown test is conservative in the sense that the probability of a false detection is less than a if the probability of false detection for the simultaneous test is a. 

To reject the null hypothesis erroneously although it is true (error of first kind, false-negative, risk a). 

Not to reject the null hypothesis by erroneously though the alternative hypothesis is true (error of second kind, false-positive, risk / ). 

This type of error equates to box B and is variously described as a type I error, a false-positive error or the a error. A type I error in a study result would lead to the incorrect rejection of the null hypothesis. 

This leads to the term Power (1 - j3), which quantifies the ability of the study to find the true differences of various values of S. It is the probability of rejecting the null hypothesis when it is false or determining that the alternative hypothesis is true when indeed it is true. 

Clinical trials are carried out to show that the null hypothesis is false. The p value is the probability of having an effect by chance if the null hypothesis were actually true. The null hypothesis is rejected in favor of the alternative hypothesis when the p value is less than a. 

If we can demonstrate to our satisfaction that the null hypothesis is false, then we can reject that hypothesis and accept the alternative hypothesis that Po 0. 

First the hypotheses must be chosen. There are two (1) the null hypothesis denoted by H sub zero which Is assumed true until rejected, and (2) the alternative hypothesis denoted by H sub one or sub A for alternative which Is assumed false until the null hypothesis Is rejected. The logic of the test requires that the hypotheses be "mutually exclusive" and "jointly exhaustive." "Mutually exclusive" means that one and only one of the hypotheses can be true "jointly exhaustive" means that one or the other of the hypotheses must be true. Both cannot be false. The null hypothesis Is to reflect the status quo, which means that failure to reject It Is only continuation of a present loss. For the agricultural station, failure to Improve the status quo means that the old brand of seed, pesticide, or fertilizer Is used when. In fact, a new and better brand Is available. This Is a status quo loss of productivity (e.g. 

Type I error (alpha error) An incorrect decision resulting from rejecting the null hypothesis when the null hypothesis is true. A false positive decision. 

We will focus our attention to the situation of non-inferiority. Within the testing framework the type I error in this case is as before, the false positive (rejecting the null hypothesis when it is true), which now translates into concluding noninferiority when the new treatment is in fact inferior. The type II error is the false negative (failing to reject the null hypothesis when it is false) and this translates into failing to conclude non-inferiority when the new treatment truly is non-inferior. The sample size calculations below relate to the evaluation of noninferiority when using either the confidence interval method or the alternative p-value approach recall these are mathematically the same. 

Tor instance, suppose the statistical criterion for testing a null hypothesis is p < 0.05. If p < 0.05, the researcher does not reject the hypothesis, because to accept the hypothesis would be to take a greater risk of treating as true a proposition that might turn out to be false. Because scientists have been historically more averse to false positives than to false negatives, they have been willing to reject hypotheses rather than take the stance of not accepting them. 

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