DNA and Nucleic Acids

This field has also inspired the development of a range of pseudo-peptides, that is polyamides composed of amino acids other than a-amino acids. These include for instance peptoids, /9-amino acid oligomers and also compounds such as peptide nucleic acids and DNA binding polyamides, all of which share the amide (peptide) chemistry with natural peptides. 

Sugars, glycoproteins, and glycolipids Complementary nucleic acids and DNA-/RNA-binding proteins Antibodies... 

Application of adsorptive stripping analysis to the determination of nucleic acids at mercury electrodes has also been reported [195]. Tomschik etal. [196] have studied reduction and oxidation of peptide nucleic acid and DNA at mercury and carbon electrodes. The authors have utilized cyclic and square-wave voltammetries to study reduction and oxidation signals of single-stranded peptide nucleic acid and DNA decamers and pentadecamers. 

Mechanism of Action. The exact mechanism of action of metronidazole is not known. It is believed that this drug is reduced chemically within the parasitic cell to a metabolite that impairs nucleic acid and DNA synthesis.32 The exact nature of this metabolite, however, and other features of the cytotoxic effects of this drug remain to be determined. 

Goemer H (1990) Phosphorescence of nucleic acids and DNA components at 77 DegK. Journal of Photochemistry and Photobiology B Biology 5 359—377. 

Tomschik, M., Jelen, F., Havran, L., Tmkova, L., Nielsen, P. E., Palecek. E. (1999). Reduction and oxidation of peptide nucleic acids and DNA at mercury and carbon electrodes. J Electroanal Chem 476, 71-80. 

Milofsky, R. E. and Yeung, E. S., Native fluorescence detection of nucleic-acids and DNA restriction fragments in capillary electrophoresis. Ana/. Chem., 65,153,1993. 

The coupling of sensitive (25 DPM above background), rapid (15 min for a 20 x 20 cm plate), scintillation counting with computerization is a major breakthrough in TLC quantification (Figure 2B). This allows in situ measurement of radioactivity, quantitative reconstruction of the nucleic acids in two or three dimensions. The ease in ability to compare prior TLC plates, generate tables for comparison, and rapidly applied statistical or analytical methods by computer is immense. This has revealed quantifiable relationship between nucleic acid and DNA chemistry that had been quite complicated to examine previously. 

Nucleic acids Complementary nucleic acids and DNA/RNA-binding proteins... 

Some more active phosphates in any living organism are ATP (adenosine triphosphate), RNA (ribose nucleic acid), and DNA (deoxyribose nucleic acid). Where orthophosphate in DNA and RNA can be considered functionally structural, as a sugar bridge in DNA and RNA, such is not the case for the tripolyphosphate moiety in adenosine triphosphate. To demonstrate adequately the activity of adenosine triphosphate it is necessary to consider the structural formula of this molecule (Figure 2.1). 

Platinum complexes as antitumor agents synthesis and testing of novel ds-platin analogues study of interactions with platinum complexes and nucleic acids and DNA fragments... 

Nikiforov, T.T. and Jeong, S. (1999) Detection of hybrid formation between peptide nucleic acids and DNA by fluorescence polarization in the presence of polylysine. Anal. Biochem. 275, 248-253. 

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