Nuclease hypersensitive elements

Further studies, both theoretical and experimental, will be needed to look at the interactions of other physiological parameters, both modelled and experimentally derived, with these PQS. Some examples include looking at the interaction between PQS and nuclease hypersensitive elements (NHEs), or with single nucleotide polymorphism (SNP) positions, or with any of a huge... 

Van Lint C, Ghysdael J, Paras P Jr, Bumy A, Verdin E (1994) A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of human immunodeficiency virus type 1. J Virol 68 2632-2648... 

Whether a gene is positioned in active or inactive chromatin certainly also plays a large role in whether or not transcription can occur. The various elements which define active chromatin (sensitivity and hypersensitivity to nucleases, presence of HMG proteins, modifications of both histone and nonhistone chromosomal proteins, DNA methylation) have recently been reviewed (Weisbrod, 1982 Razin and Riggs, 1980). With a few exceptions, there is no clear idea how the DNA sequences and proteins which are known to modulate transcription relate to the formation of active chromatin. Such a discussion must therefore be deferred to a later date. 

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