Nuclear receptor Multiplicity

Hermanson O, Glass CK, Rosenfeld MG Nuclear receptor coregulators multiple modes of receptor modification. Trends Endocrinol Metab 2002 13 55. 

McKenna NJ, Xu J, Nawasz Z, Tsai SY, O Malley BW (1999) Nuclear receptor coactivators multiple enzymes, multiple complexes, multiple functions. J Steroid Biochem Mol Biol 69 3-12... 

Steroid receptors contain multiple functional domains (Fig. 3) that are modular and whose sequences can be extensively conserved across the superfamily. Thus it is not surprising that there is considerable cross talk between and among members of the superfamily and their various shared partner proteins. As will be evident from Table 3, there is considerable overlap in the spectrum of enzymes regulated by nuclear receptors. Many examples exist wherein an individual nuclear receptor regulates multiple enzymes (16). 

No functional polymorphisms have been reported in human CAR, the major nuclear receptor that mediates CYP2B6 induction. However, PXR, which also plays a significant role in CYP2B6 induction, exists as multiple allelic variants, some of which alter transactivation function of this receptor (122,123). 

Fang C, Yoon S, Tindberg N, Jarvelainen HA, Lindros KO, Ingelman-Sundberg M. Hepatic expression of multiple acute phase proteins and down-regulation of nuclear receptors after acute endotoxin exposure. Biochem Pharmacol 2004 67 1389-1397. 

Zhou D, Quach KM, Yang C, Lee S Y, Po-hajdak B, Chen S. 2000. PNRC a proline rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptorss including orphan receptors SF1 and ERRalpha. Mol. Endocrinol. 14 986—98... 

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