Nuclear medicine diagnostic

Metal-metal (M-M) bonds, first noted in the early sixties, occur in several thousand transition-metal compounds [1]. Complex technetium compounds and compounds with M-M bonds (clusters) have been studied more extensively than many other classes of inorganic compounds. Increasing interest in technetium compounds is due to the practical uses of the "mTc isotope, which ranks first among radioactive isotopes used in nuclear medicine diagnostics [2-4]. On the other hand, technetium clusters are an interesting object for theoretical studies, because until recently, they were the only compounds in which the presence of these anomalous chemical bonds was thought possible. 

Staff preparing radiopharmaceuticals to be administered for nuclear medicine diagnostic and therapeutic procedures and handling sealed sources for brachytherapy use protective blocks to shield the head and trunk. For these workers, a single personal monitor is located on the trunk. ... 

Radionuclide generator Powell Richards and Walter Tucker and their colleagues at Brookhaven Laboratory in New York invent a short half-life radionuclide generator for use in nuclear medicine diagnostic imaging procedures. 

An X-ray fluorescence scanner is at least as expensive as an analogous piece of equipment for the classical scintigraphy complete with all the necessary accessories. The latter is therefore suitable for use in all field in which in vivo nuclear medicine diagnostics are valuable. An X-ray fluorescence scanner developed and built for thyroid investigations may be used to obtain morpho-functional images only of the thyroid besides, these images show a not better resolution than that of radionuclides images. 

Nuclear instrumentation can be found in many different Institutions there are nuclear research centres, universities, and hospitals with their nuclear medicine diagnostic or therapy units. In industry, radiation and associated nuclear instruments are applied in products and in process control. As a rule, nuclear instruments are rather sophisticated and delicate instruments. If they develop faults, as any instruments sooner or later do, they are not easy to repair. Considerable specialized knowledge, extensive experience, and suitable equipment is needed for their repair and servicing. 

In view of the importance to diagnostic nuclear medicine of "mTc radiopharmaceuticals containing the [99mTcvO]3+ and [99mTc02]+ cores [11,12,91], there... 

Until the mid 1970s, technetium(V) had been widely ignored and its chemistry misinterpreted. Then, the development of the chemistry of technetium(V) was prompted by the trends and needs of nuclear medicine, which predominantly uses technetium-99m radiopharmaceuticals for a broad range of diagnostics. 

The utilization of radioisotopes in the field of nuclear medicine has been promoted for various purposes. Among them, diagnostic applications have had much success during the past two decades. Technetium-99m, thallium-210 and iodine-123, for example, have been used as radioisotopes for imaging studies. 

Metals continue to play an important role in radiopharmaceuticals for diagnostic and therapeutic applications in nuclear medicine. Radiopharmaceuticals are drugs that contain a radionuclide and are used for imaging if the radionuclide is a photon emitter (gamma (7) or positron (/3+)) or for... 

James S. Robertson Diagnostic Nuclear Medicine Mayo Clinic Rochester, Minnesota... 

Scintigraphic imaging is a noninvasive imaging technique commonly applied in nuclear medicine. Radiolabeled compounds (called radiopharmaceuticals or radiotracers) are administered intravenously to patients for diagnostic or, in certain cases, therapeutic purposes. The in vivo distribution can provide important physiological information about tissue function. 

Recently, the potential of organometallic iminophosphoranes as synthetic components for radiopharmaceutical agents has been reported. In nuclear medicine Rh is currently being used as a radioisotope for diagnostics and cancer therapy. A complex of Rh with organometallic iminophosphoranes, such as 43 (Scheme 22), could represent a novel type of radiopharmaceutical [93ZN(B)1381]. 

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