Radiopharmaceutical agents

Werner s coordination theory, 1, 6 Whewellite structure, 6, 849 Wickmanite structure, 6, 849 Wilkinson s catalyst, 6, 239 Wilson s disease, 5, 721 copper, 6,648 removal, 6,769 copper complexes, 2,959 copper metabolism, 6,766 radiopharmaceutical agents, 6,968 Wolfram s red salt, 5,427 Wurzite... 

In this section the in vitro reactivity of various octahedral complexes of technetium and rhenium are discussed and correlated with the in vivo pharmacokinetic data as observed for currently used radiopharmaceutical agents, which in most cases are indeed octahedral complexes of these metal centers. 

Recently, the potential of organometallic iminophosphoranes as synthetic components for radiopharmaceutical agents has been reported. In nuclear medicine Rh is currently being used as a radioisotope for diagnostics and cancer therapy. A complex of Rh with organometallic iminophosphoranes, such as 43 (Scheme 22), could represent a novel type of radiopharmaceutical [93ZN(B)1381]. 

The Class II formulations are the so called technetium essential radiopharmaceuticals whose biodistribution depends not only on the nature of the substrate to be labelled, but also on the presence of "mTc itself. Some examples of the major types of "mTc radiopharmaceutical agents in use, or under investigation, are summarized in Table 22. The nature of the "mTc binding site... 

In Vivo Procedures In vivo studies—those that take place inside the body—are carried out to assess the functioning of a particular organ or body system. A radiopharmaceutical agent is administered, and its path in the body—whether it is absorbed, excreted, diluted, or concentrated—is determined by analysis of blood or urine samples. 

Ga ° which have been verified as a hydrophilic blood labeling agent (Tc), as tracer for platelets labeling (In) and as radiopharmaceutical agents (In and Ga). 

Gatley SJ (1996) Positron radiopharmaceutical agents and their chemistry. In Henkin RE, Boles MA, DUlehay GL, Halama JR, Karesh SM, Wagner RH, Zimmer AM (eds) Nuclear medicine. Mosby, St Louis, pp 429-444... 

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