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Nuclear hormone receptors assay

The translocation of a nuclear hormone receptor to the nucleus is an early stage of receptor activation. A number of assay technologies can detect this nuclear translocation event. For example, using... [Pg.54]

Chapter 3 Assay Development for Nuclear Hormone Receptors.49... [Pg.285]

This technology is highly sensitive and DiscoveRx has developed several assays to measure cAMP [212], tyrosine or serine kinase [213], nuclear hormone receptors and proteases [214], as weU as assays for the measurement of cellular protein expression [211]. [Pg.649]

Steroid hormones achieve their effects on target tissues through intracellular receptor proteins. According to recent views, oestrogen and progestin receptors are localized in the nuclear compartment of the cells, whereas glucocorticoid receptors may reside in both the cytoplasm and the nucleus. Determination of the intracellular localization of androgen receptors awaits the development of (monoclonal) antibodies which will enable immunohistochemical studies. The molecular aspects of the mechanism of action of steroid hormones will be covered in other chapters [1-3] in this volume. The present chapter deals with the characterization, assay and purification of steroid receptors. [Pg.49]

In addition to the actions mediated by intracellular receptors, steroid hormones also demonstrate certain rapid (occurring within seconds) actions, which appear to be mediated by membrane effects/receptors this is true for vertebrate [114] and invertebrate [115] steroids. One presumes that the SAR studies for ecdysteroids which have been performed to date are predominantly determined by interaction of ecdysteroids with nuclear receptors, but one should bear in mind that in certain assay systems the... [Pg.16]

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