NSC-45388

Dactlnomydn, USP. Cosinegen. actinomycin D. acti-nomycin C. actinomycin IV. NSC-3053, is obtained from the fermentation of selected strains of Sireplomyces parvu-Ills. It is soluble in alcohols and alcohol-water mixtures however, these solutions are very sensitive to light. Vials containing 0.5 mg of lyophilized powder of the drug and 20 mg of mannitol are supplied. For reconstitution. I.l mL of Sterile Water for Injection. USP is added to the vial. The re.sulting solution is stable for 2 to 5 months at room temperature. 

Of the numerous anticancer drugs, eight have been reported to form free radicals, namely doxorubicin (= adriamydn = NSC-123127), daunorubicin (= daunomycin = NSC-83142), mitoxantrone (= NSC-301379), bleomycin (= NSC-125066), neocarzinos-tatin (= NSC-157365), mitomycin C (= NSC-26980), actinomycin D (= NSC-3053), and procarbazine (= NSC-77213). 

Actmomycin D (= NSC-3053 1 ig/ml) in foetal baboon lung explants exposed to hyperoxia (95%... 

Fluorouracil (NSC-19893) and actino-mycin D (NSC-3053) in the treatment of acute leukaemia in children. Cancer Chemother. Rep., 57, 335. 

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