Bleomycin NSC

Bleomycins, NSC-125066 Bleo. A group of related glycopeptide antibiotics isolated from Streptomyces venlciiius Umezawa Antimlcrob, Ag. Chemother. 1965 ... 

Of the numerous anticancer drugs, eight have been reported to form free radicals, namely doxorubicin (= adriamydn = NSC-123127), daunorubicin (= daunomycin = NSC-83142), mitoxantrone (= NSC-301379), bleomycin (= NSC-125066), neocarzinos-tatin (= NSC-157365), mitomycin C (= NSC-26980), actinomycin D (= NSC-3053), and procarbazine (= NSC-77213). 

Ihde, D. C., Gormley, P. E., Francis, R. S. and DeVita, V. T. (1975) Reversible penile calcifications associated with bleomycin (NSC-125066) induced pulmonary toxicity. Cancer Chemother. Rep., 59,5. 

Samuels, M. L., Johnson, D. E. and Holoye, P. Y. (1975) Continuous intravenous bleomycin (NSC-125066) therapy with vinblastine (NSC-49842) in stage HI testicular neoplasia. Cancer Chemother. Rep., 59, 563. 

NSC-409962) and bleomycin (NSC-125066) in the treatment of Kaposi s sarcoma. Cancer Chem-other. Rep., 57, 325. 

Sodium phenobarbital Oxathiin carboxanilide Physostigmine Perilla ketone (NSC 348407) Peptides Somatotropin Physostigmine Etoposide Bleomycin... 

DIC (NSC 45388) is found to be active against mouse leukemia L 1210, sarcoma 180 and adenocarcinoma. BIC was found to be most potent suggesting thereby that halo-substitution are often more potent in antineoplastic activity. At present DIC is mostly employed in malignant malanoma. It is used in combination with adriamycin, bleomycin and vinblastine in the treatment of Hodgkin s diseases and in sarcomas with adriamycin. 

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