NSAIDs Thyroid hormones

Slc21a4) taurocholate, thyroid hormones Drugs AZT, MTX Drugs NSAIDs, furosemide, valproate... 

One of the first SULTlAl inhibitors identified in the rat liver was 2, 6-dichloro-4-nitrophenol (DCNP) (Mulder and Scholtens, 1977). DCNP is a dead-end inhibitor, and exhibits low IC50 values toward SULTlAl and SULT 1 A3 (Seah and Wong, 1994). Hydroxylated polychlorinated biphenyls (HPCBs) are potent inhibitors of recombinant human SULTIEI. HPCBs exhibit low micromolar IC50 values toward thyroid hormones (Schuur et al., 1998). Several dietary chemicals such as quercetin, curcumin, and flavones are known to inhibit SULTs. Some commonly used drugs that inhibit SULTlAl and SULT1A3 activity include NSAIDs such as mefenamic acid, naproxen, and salicylic acid. 

Treatments for autoimmune disease have traditionally been immunosuppressive, antiinflammatory or palliative. Non-immunological therapies, such as hormone replacement in Hashimoto s thyroiditis, treat the outcomes of the autoaggressive response. Dietary manipulation limits the severity of coeliac disease. Steroidal or NSAID treatment limits the inflammatory symptoms of many diseases. 

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