Nramp family

Portnoy, M. E., Liu, X. F. and Culotta, V. C. (2000). Saccharomyces cerevisiae expresses three functionally distinct homologues of the Nramp family of metal transporters, Mol. Cell Biol., 20, 7893-7902. 

Nevo Y, Nelson N. The NRAMP family of metal-ion transporters. Biochim. Biophys. Acta 2006 1763 609-620. 

Seefeldt, L. C., Hoffman, B. M., Dean, D. R. (2009). Mechanism of Mo-dependent nitrogenase. The Annual Review ofBiochemistry, 78,701—722. Ueki, T, Furano, N., Michibata, H. (2011). A novel vanadium transporter of the Nramp family expressed at the vacuole of vanadium-accumulating cells of the ascidian Ascidia sydneiensis samea Biochimica et Biophysica Acta, 1810, 457—464. 

Agranoff, D., I.M. Monahan, J.A. Mangan, P.D. Butcher and S. Krishna. Mycobacterium tuberculosis expresses a novel pH-dependent divalent cation transporter belonging to the Nramp family. J. Exp. Med. 

Min-Oo G, Fortin A, Tam MF, Nantel A, Stevenson MM, Gros P 2003 Pyruvate kinase deficiency in mice protects against malaria. Nat Genet 35 357—362 Poon A, Schurr E 2004 The NRAMP genes and human susceptibility to common diseases. In Gellier M, Gros P (eds) The Nramp Family. Kluwer Academic/Plenum Publishers, New York, NY p 29-43... 

Thomine, S., Wang, R., Ward, J. M., Crarvford, N. M., and Schroeder, J. I., 2000, Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes, Proc. Natl. Acad. Sci. U.S.A. 97 4991-4996. 

A number of genes involved in metal transport in plants have been identified. Many of these belong to previously described transporter families such as the P-type APTases (Axelsen et al. 1998) and the Nramp proteins (natural resistance-associated macrophage protein) (Cellier et al. 

Rodrigues V, Chia Wand Geos P (1995) Nramp defines a family of membrane proteins. Proc Natl Acad Sci USA 92 10089-10093. 

Heavy metal ions are both essential for life and toxic at high concentrations. Eight families of secondary active transporters are known to mediate divalent cation uptake and/or efflux (Nramp, VIT, ZIP, and NiCoT for uptake and CaCA, CDF, CadD, and RND/HME for efflux). In LAB, two of... 

Protein families involved in vacuolar sequestration may be the NRAMP s, CDF s, and CAX s (reviewed by Hall and Williams [102]) as well as CPx-type ATPases. Until now, already several transporters for vacuolar sequestration of zinc (and possibly cadmium) and nickel have been investigated and could be partially characterized [103-107]. Several CDF transporters for vacuolar sequestration of Zn (and possibly Cd and Co) have been characterized, all are homologous, almost identical in sequence. These are MTPl, ZAT, and ZTP (e.g., [88,89,103,108]). The strongly elevated expression of the CPx-type metal ATPase HMA3 was shown to play a decisive role in Cd accumulation not only in T. caerulescens [109], but also in rice [110,111], reconfirming also the importance of the sequestration into vacuoles for the hyperaccumulation phenotype. The natural over-expression of NRAMPs was identified both in rice and in T. caerulescens to play an important role in Cd tolerance and possibly Cd accumulation [112-114]. When vacuolar... 

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