Natural resistance-associated macrophage proteins

Nramp Natural resistance associated macrophage proteins ... 

WyUie S, Seu P, Goss JA. The natural resistance-associated macrophage protein 1 Slcllal (formerly Nrampl) and iron metabolism in macrophages. Microbes Infect 2002 4 351-9. 

Chen, H., G.C. Waldbieser, C.D. Rice, B. Elibol and L.A. Hanson. Isolation and characterization of a channel catfish natural resistance associated macrophage protein (Nramp) gene. Dev. Comp. Immunol. 26 517-531, 2002. 

Saeij, J.P., G.F. Wiegertjes and R.J.M. Stet. Identification and characterization of a fish natural resistance-associated macrophage protein (Nramp) cDNA. Immunogenetics 50 60-66, 1999. 

Natural resistance-associated macrophage protein (NRAMP1). Iron transporter that plays a critical role in macrophage activation and differentiation. Allele 3 of the NRAMP1 promoter is associated with autoimmune disorders (e.g. rheumatoid arthritis, juvenile rheumatoid arthritis, diabetes mellitus type 1, multiple sclerosis). 

A number of genes involved in metal transport in plants have been identified. Many of these belong to previously described transporter families such as the P-type APTases (Axelsen et al. 1998) and the Nramp proteins (natural resistance-associated macrophage protein) (Cellier et al. 

Allele frequencies in natural resistance associated macrophage protein (NRAMP) gene may play a role in susceptibility of African American versus Caucasian populations to sarcoidosis (Maliarik et al. 1996). In a case control study of 157 African American patients with sarcoidosis and 111 African American control subjects, Maliarik et al. (2000) found - in contrast to those in tuberculosis patients - the less common genotypes of NRAMP gene more often in control subjects than in case patients. In particular, one polymorphism, a (CA)n repeat in the intermediate 5 region of the gene, was found to have a protective effect (P = 0.014). 

A number of recent studies established the basis of the toxicokinetic interaction of Fe with Pb. This interaction appears to occur through operation of the divalent metal transporter 1 (DMTl), also known as the natural resistance-associated macrophage protein 2 (NRAMP2), the divalent cation transporter 1 (DCTl) (Bressler et al., 2004, 2007 Gu et al., 2009 Kayaalti et al., 2010 Mims and Prchal, 2005). 

A number of candidate genes have been examined by association. The natural resistance-associated macrophage protein gene (NRAMP) has been associated with susceptibility to tuberculosis. Because of the histopathological similarities with tuberculosis, the association with sarcoidosis was studied (120). A (CA)(n) repeat in the immediate 5 region of the gene was overrepresented in 157 African American patients compared with ethnically matched controls, although the implicated polymorphism differed from both of the two SNPs associated with TB susceptibility. 

Maliarik MJ, Chen KM, Sheffer RG, et al. The natural resistance-associated macrophage protein gene in African Americans with sarcoidosis. Am J Respir Cell Mol Biol 2000 22(6) 672-675. 

NRAMP2 natural resistance-associated macrophage protein-2... 

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