NOX proteins

Ambasta, R.K., Kumar, P, Griendling, K.K., Schmidt, H.H., Busse, R. and Brandes, R.P (2004) Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J. Biol. Chem. 279, 45935 5941. 

Other proteins from the Bcl-2 family are proapoptotic. The proapoptotic group is subclassified into BH3-only proteins (Bid), BH3-only with a transmembrane domain (Bad, Bim, Bik, Bmf, Hrk, Nox, or Puma), and multi-BH (BHl, 2, 3)... 

DOT CLASSIFICATION 9 Label None SAFETY PROFILE Deadly poison by ingestion in humans. The seeds contain the deadly poison ricin, a plant lectin (toxalbumin) which inhibits protein synthesis in the intestinal wall. Ingestion of the seeds can cause after a delay period of several hours nausea, vomiting, diarrhea, and intestinal dysfunction. There may be massive fluid and electrolyte loss. Ingestion of as few as 2 seeds could be fatal. A potent allergen. When heated to decomposition it emits toxic fumes of NOx. See also RICIN. 

Figure 3 Soluble guanylate cyclase, (a). Domain architecture of sCC. sGC consists of two homologous subunits, al and pi. Each subunit contains an N-terminal H-NOX domain, a central predicted PAS-like region, and a C-terminal catalytic domain. Heme (gray parallelogram) binds to the H-NOX domain on the pi subunit, (b). NO activation of sGC. NO binds to the sCC heme, which leads to the formation of a 5-coordinate ferrous nitrosyl complex and activates the protein several-hundred-fold above the basal level.

Fig. 6.17 Reactions of NO in biological systems. NO reacts in biological systems primarily with 02, with the superoxide anion 02 and with transition metals (Me). The products of the reaction, -NOx, metal-NO adducts (Me-NO) and peroxynitrite (OONO ) react further by nitro-sylation of nucleophilic centers. In the cell, these are especially -SH (or thiolate-S ) groups of peptides and proteins (RS).

Hazardous Decomp. Prods. Heated to decomp., emits toxic fumes of POx and NOx Uses Biochemical research energy carrier in plants and animals energy source within the cell for biological processes such as photosynthesis, muscle contraction, and the synthesis of proteins neurotransmitter biological additive, skin conditioner in cosmetics ingred. in tanning accelerator complexes... 

Protamide LMFAB. See Lauramide DEA Protamide LNO. See Linoleamide DEA Protamide MEAA. See Acetamide MEA Protamide MRCA. See Myristamide DEA Protamide SA. See Stearamide DEA Protamide X-45-B. SeeCocamide DEA Protamine sulfate CAS 9009-65-8 53597-25-4 Synonyms Salmine sulfate Definition Mixt. of simple proteins obtained from the sperm or testes of certain species of fish has property of neutralizing heparin Toxicoiogy LD50 (IP, rat) 120 mg/kg, (IV, rat) 75 mg/kg, (subcut., mouse) 200 mg/kg poison by IP, IV, subcut. routes human systemic effects (anaphylaxis, blood pressure decrease, decreased urine vol.) TSCA listed Hazardous Decomp. Prods. Heated to decomp., emits very toxic fumes of NOx and SOx Uses Pharmaceuticals (parenterals, injectables)... 

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