Norfloxacin drug interactions

More recently Brochot et al. [89] reported an extension of the isobolographic approach to interaction studies for convulsant interaction among pelloxacin, norfloxacin, and theophylline in rats. Their contribution is unique in that they started out by explaining pharmacodynamic interactions for two drugs, but then extended the approach to derive an isobol for three drug interaction. In addition they included Bayesian analysis and developed a population model with Markov chain Monte Carlo methods. 

B. Pharmacokinetics. Caffeine is rapidly and completely absorbed orally with a volume of distribution of 0.7-0.8 L/kg. Its elimination half-life is approximately 4-6 hours but can range from 3 hours in healthy smokers to 10 hours in non-smokers after overdose the half-life may be as long as 15 hours. In infants less than 2-3 months old, metabolism is extremely slow and the half-life may exceed 24 hours. (See also Table 11-59.) Caffeine is metabolized in the liver by cytochrome P-450, primarily the CPY 1A2 isoenzyme, and is subject to several potential drug interactions, including inhibition by estrogens, cimeti-dine, norfloxacin, and alcohol. Tobacco (and marijhuana) smoking accelerates caffeine metabolism. 

CIPROFLOXACIN, LEVOFLOXACIN, NALIDIXIC ACID, NORFLOXACIN ANTIGOUT DRUGS -PROBENECID t ciprofloxacin, nalidixic acid and norfloxacin levels Uncertain Watch for T incidence of side-effects. Moxifloxacin, ofloxacin and spar-floxacin do not seem to interact and could be used as alternative therapy... 

Cordoba-Diaz M, Cordoba-Borrego M, Cordoba-Diaz D. Influence of pharmacotechnical design on the interaction and availability of norfloxacin in directly compressed tablets with certain antacids. Drug Dev Ind Pharm 2000 26(2) 159-66. 

Brochot C, Marchand S, Couet W, Gelman A, Bois FY. Extension of the isobolographic approach to interactions studies between more than two drugs Illustration with the convulsant interaction between pefloxacin, norfloxacin, and theophylline in rats. J Pharm Sci 2004 93 553-62. 

Information about the interactions with calcium carbonate is more limited than with the aluminium/magnesium antacids, but Table 10.3 , (p.329) shows that the bioavailabilities of ciprofloxacin and norfloxacin, and to a lesser extent gemifloxacin, can be reduced. These reductions are less than those seen with the aluminium/magnesium antacids, but using ciprofloxacin as a guide a very broad rule-of-thumb would be to separate the drug administration by about 2 hours to minimise this interaction. This is clearly not necessary with levofloxacin, lomefloxacin, moxifloxacin or ofloxacin, nor probably with some of the other qui-... 

Probenecid increases the serum ieveis and/or decreases the urinary excretion of cinoxacin, ciprofloxacin, clinafloxacin, enoxacin, fleroxacin, levofloxacin, nalidixic acid and norfloxacin. The ciinicai importance of these changes is uncertain, but is seems iikeiy they wiii oniy be important in the presence of other drugs that aiso affect renai excretion. Grepafloxacin, moxifloxacin, sparfloxacin, and probably ofloxacin, appear not to interact with probenecid. 

Health Canada had received 6 reports of suspected coagulation disorders associated with norfloxacin and warfarin, 4 of which were considered serious. Similarly, in February 2006, the Australia Adverse Drug Reactions Advisory Committee stated they had received 11 reports of a suspected interaction between warfarin and norfloxacin. ... 

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