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Noradrenaline reuptake inhibitors NARIs

Taken together, the efficacy of antidepressants covers the spectrum of anxiety disorders, although there are important differences between drugs in the group (Table 3). Several new antidepressants have been marketed since the SS-RIs venlafaxine and mirtazapine are discussed later (Sects. 3.2.1.2 and 3.2.1.4) nefazodone, a serotonin reuptake inhibitor and postsynaptic 5-HT2 blocker showed promise in early studies but was recently withdrawn by its manufacturers reboxetine, a noradrenaline reuptake inhibitor (NARI) showed benefits in panic disorder in one published study (Versiani et al. 2002) and further evidence of its anxiolytic efficacy is awaited. [Pg.479]

Noradrenaline (norepinephrine) reuptake inhibitors (NARIs) Serotonin and noradrenaline (norepinephrine) reuptake inhibitors (SNRIs) Atypical... [Pg.175]

Reboxetine, was the first antidepressant to be developed to work specifically on noradrenaline (Wong et al., 2000). It is a specific noradrenergic reuptake inhibitor (NARI) and in a clinical study, it was found to improve the psycho-social functioning of depressed patients, as measured by the Social Adaptation Self-evaluation Scale (SASS), more than fluoxetine, a specific serotonergic reuptake inhibitor (SSRI) antidepressant (Dubini, Bose, and Polin, 1997). It has been suggested that social adaptation as measured on the scale used (SASS) is associated with the concept of social motivation (Charles et al., 1999). The improvement, thus, appeared to be associated with enhancement of social motivation which might be important for the therapeutic recovery process (Hirschfeld, et al., 2000). However, the mechanism by which the changes in noradrenaline induced by reboxetine led to improvement on the SASS is unknown. [Pg.55]

Reboxetine Morpholine Selective noradrenaline reuptake inhibitor (NRI or NARI)... [Pg.93]

Within each class or subclass drugs are listed in order of frequency of prescription in the United Kingdom (1997 data). Abbreviations RIMA—reversible inhibitor of monoamine oxidase NaRI—noradrenaline reuptake inhibitor SNRI—serotonin and noradrenaline reuptake inhibitor NaSSA—noradrenaline and specific serotonergic antidepressant. [Pg.369]

Moderate affinity for the specific receptor/transporter NARI Selective noradrenaline (norepinephrine) reuptake inhibitor... [Pg.40]


See other pages where Noradrenaline reuptake inhibitors NARIs is mentioned: [Pg.439]    [Pg.144]    [Pg.439]    [Pg.144]    [Pg.439]    [Pg.370]    [Pg.213]    [Pg.174]    [Pg.366]   


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