Noradrenergic reuptake inhibitors

Kavapyrones seem to be the therapeutically active constituents. Kava appears to influence a number of monoamine, amino acid, and neuropeptide transmitters in the CNS. Animal studies suggest that kava activates mesolimbic dopaminergic neurons (e.g., in the nucleus accumbens) while also altering 5-HT levels in various brain regions (Baum et ah, 1998). Kava may also act as a reversible MAO inhibitor and a noradrenergic reuptake inhibitor (Uebelhack et ah, 1998). 

Classical Antidepressants, Serotonin Selective Reuptake Inhibitors, and Noradrenergic Reuptake Inhibitors... 

Reboxetine, was the first antidepressant to be developed to work specifically on noradrenaline (Wong et al., 2000). It is a specific noradrenergic reuptake inhibitor (NARI) and in a clinical study, it was found to improve the psycho-social functioning of depressed patients, as measured by the Social Adaptation Self-evaluation Scale (SASS), more than fluoxetine, a specific serotonergic reuptake inhibitor (SSRI) antidepressant (Dubini, Bose, and Polin, 1997). It has been suggested that social adaptation as measured on the scale used (SASS) is associated with the concept of social motivation (Charles et al., 1999). The improvement, thus, appeared to be associated with enhancement of social motivation which might be important for the therapeutic recovery process (Hirschfeld, et al., 2000). However, the mechanism by which the changes in noradrenaline induced by reboxetine led to improvement on the SASS is unknown. 

Noradrenergic reuptake inhibitors such as desipramine can be used as a second-line treatment for smoking cessation, cocaine dependence, and attention deficit disorder... 

Oosterhuis I, Heijting L, van Puijenbroek E. Spontaneous ejaculation with the use of noradrenergic reuptake inhibitors. Eur J Chn Pharmacol 2012 68(10) 1461-2. 

---