Nondepolarizing neuromuscular blocking drugs

Minimal cardiovascular effects duration of action prolonged in renal failure 

Atracurium Solution Short duration of action may require 

Halothane, enflurane, and isoflurane potentiate the activity of doxacurium, and phenytoin and carbamazepine shorten the duration of doxacurium block. 

Salicylates and allied compounds have analgesic, antipyretic, uricosuric, and antiinflammatory properties. Then-mechanisms of action differ from those of the antiinflammatory steroids and the opioid analgesics. They are classified into the following categories (see Table 3). 

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Atracurium spontaneously degrades in plasma and is the only nondepolarizing neuromuscular blocking drug whose dose need not be reduced in patients with renal failure. 

Clindamycin and hncomycin potentiate the action of nondepolarizing neuromuscular blocking drugs, such as pancuronium and D-tubocurarine. The lincosamide-induced block cannot be reliably reversed pharmacologically (71). 

Nondepolarizing neuromuscular blocking drugs Nonsteroidal antiinflammatory drugs Nursing infants pharmacology of Obesity treatment of Oculotoxicity drug-induced Opioid peptides... 

On the other hand, more complex structures based on the tubocurarine molecule led to laudexium (18) and as knowledge of the structural requirements for nondepolarizing neuromuscular-blocking drugs became clearer, it laid the basis for a less empirical and more positive approach to the design of appropriate drugs. The considerations taken into account include the following ... 

Drugs that may interact with capreomycin include aminoglycosides and nondepolarizing neuromuscular blocking agents. 

Structures of some isoquinoline neuromuscular blocking drugs. These agents are all nondepolarizing muscle relaxants. 

All of the available neuromuscular blocking drugs bear a structural resemblance to acetylcholine. In fact, succinylcholine is two acetylcholine molecules linked end-to-end (Figure 27-2). In contrast to the single linear structure of succinylcholine and other depolarizing drugs, the nondepolarizing... 

There are two types of neuromuscular blocking drugs used during surgery nondepolarizing neuromuscular blockers and depolarizing neuromuscular blockers. 

ATC M03AC09 Use neuromuscular blocker, nondepolarizing blocking drug... 

Drugs that may be affected by benzodiazepines include digoxin, neuromuscular blocking agents (nondepolarizing), and phenytoin. 

Muscle Isoflurane produces some relaxation of skeletal muscle via its central effects. It also enhances the effects of depolarizing and nondepolarizing muscle relaxants. Isoflurane is more potent than halothane in its potentiation of neuromuscular blocking agents. The drug relaxes uterine smooth muscle and is not recommended for analgesia or anesthesia for labor and vaginal delivery. 

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