Noncovalent interactions synthesis

The gel properties will also be influenced by many other parameters including the nature of the cross-links, synthesis conditions, type and concentration of initiator used, phase separation, and the presence of noncovalent interactions such as hydrogen bonding and hydrophobic interactions. Nonetheless, the gel properties depend primarily upon the monomers used. 

The synthesis, spectral properties, and applications of symmetrical as well as unsymmetrical, hydrophobic oxo-squaraine probes for noncovalent interaction with proteins, lipids, cells, and other high-molecular-weight analytes are described in numerous publications and patents [52, 57, 58]. 

While the convergent strategy, as described above, has been exceptionally successful, a considerable amount of effort has been devoted to improving its speed and synthetic efficiency. The remainder of this chapter reviews the major methodological developments and improvements in the accelerated, covalent, convergent synthesis of dendrimers. Dendrimers constructed via self-assembly and noncovalent interactions, as well as inorganic dendrimers [25], are beyond the scope of this brief chapter. 

Noncovalent interactions play a special role in synthetic procedures used to assemble various types of supramolecular species. These syntheses rely on the stabilization provided by non-covalent interactions between recognition sites incorporated within precursors. Various types of non-covalent interactions can be used as a recognition motif utilized to guide the synthesis.Targeted synthesis of macro- and supramolecular structures of various sizes, shapes, and functionality has now become possible. Supramolecular chemistry offers incredible applications in various fields such as medicinal chemistry (drug delivery systems),host-guest chemistry,catalysis,and molecular electronics. ... 

Roland JT, Ma SX, Nguyen M, Guan Z. Synthesis of titin-mimicking polymers having modular structures by using noncovalent interactions. Polym Prepr 2003 44 726-727. 

In this approach, well-dehned subunits (small molecules similar to, e.g., nucleotides) tire first formed through covalent synthesis, Second, these subunits aggregate with themselves or with other subunits through covalent or noncovalent (or both) interactions to form large, stable, structurally defined assemblies. For the final supramolecular structure to be stable and to have a well-defined shape, the noncovalent connections must be collectively stable. Therefore, molecules must be stabilized by many noncovalent interactions. 

The use of noncovalent interactions has been exploited for the synthesis of, for example, receptor-functionalized nanoparticles and/or SAMs with molecular recognition abilities at the interface. The advantage of noncovalent interactions over covalent bonding is that the former offer the possibility for error correction.21... 

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