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Noncovalent Drug Delivery Systems

Maleic copolymers, especially those with alkyl vinyl ethers, were used in drug formulations where only physical interactions occurred between the polymer matrix and the therapeutic agent. The polymers used in the formulations should be biocompatible, nontoxic, and should not induce allergic or pyrogenic reactions. Poly(maleic anhydride-co-methyl vinyl ether) (MA-MVE) is such a polymer, being approved by the FDA. Commercialized as Gantrez AN, MA-MVE copolymer is used as pharmaceutical excipient due to its bio/mucoadhesion and excellent film-forming properties [137]. [Pg.291]

Noncovalent interactions play a special role in synthetic procedures used to assemble various types of supramolecular species. These syntheses rely on the stabilization provided by non-covalent interactions between recognition sites incorporated within precursors. Various types of non-covalent interactions can be used as a recognition motif utilized to guide the synthesis.Targeted synthesis of macro- and supramolecular structures of various sizes, shapes, and functionality has now become possible. Supramolecular chemistry offers incredible applications in various fields such as medicinal chemistry (drug delivery systems),host-guest chemistry,catalysis,and molecular electronics. ... [Pg.152]

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Noncovalent

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