Non-neoplastic cells

Obermuller-Jevic et al. (2003) comparison PrEC-non-neoplastic cells M -trans/5% cis isomers 0.5—5.0pM THF affected cell cycle, corrected for THF alone values 48 h medium changed every 24 h Lycopene uptake 3H thymidine incorporation for proliferation... 

Hama K, Aoki J, Fukaya M, Kishi Y, Sakai T, Suzuki R, Ohta H, Yamori T, Watanabe M, Chun J, Aral H (2004) Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPAI. J Biol Chem 279 17634-17639... 

TABLE 4.1 C) tokeratin Subclasses and Non-neoplastic Cell Types Expressing Them ... 

Hibbs, J.B., Jr. (1974). Discrimination between neoplastic and non-neoplastic cells in vitro by activated macrophages. J. Natl. Cancer Inst. 53,1487-1492. 

Since HU needs to be taken lifelong in the treatment of non-neoplastic conditions such as SCA (since the inhibition of ribonucleotide reductase is reversible) a major concern is its long term secondary effects. Several studies have shown the potential leukomegenic effect of HU in myeloproliferative disorders [22], [23]. Such concern becomes quite legitimate in sickle cell patients with permanently expanded erythropoiesis in whom the use of HU is at the limit of marrow toxicity. Hence alternative therapies must be sought for. 

In humans, epithelial cells of the flat non-neoplastic colonic mucosa of individuals with colon cancer often have reduced capacity to undergo DOC-induced... 

Additionally, two studies have measured colorectal epithelial cell proliferation and apoptosis in human non-neoplastic mucosa in combination with serum bile acid quantification. Ochsenkuhn et al have reported a positive correlation between serum DCA levels and proliferation measured by flow cytometric cell cycle analysis. However, a more recent study of colorectal adenoma patients failed to detect a correlation between serum DCA and immuno-histochemical Ki-67 antigen labelling. Instead, this latter study revealed a positive correlation between serum DCA and the degree of TUNEL-positive epithelial cell apoptosis. ... 

In a two-year study (United States National Toxicology Program, 1989 Kari et al., 1992), dose-dependent hepatic morphological changes (anisokaryosis, elevated frequency of multinucleated cells) were observed in male mice. In a long-term feeding study (0.8% in the diet) (Shibata et al., 1991), hepatic centrilobular hypertrophy was observed in males and forestomach hyperplasia in both males and females, while no non-neoplastic changes in the kidney were reported. 

J2. Jones, H. E., Eaton, C., Barrow, D., Dutkowski, C., and Griffiths, K., Response of cell growth and retinoic acid receptor expression to retinoic acid in neoplastic and non-neoplastic prostate cell lines. Prostate 30, 174-182 (1997). 

Monticello et al. (1996) assessed the role of regional increases in nasal epithelial cell proliferation in the formation of formaldehyde-induced nasal neoplastic and non-neoplastic tissue damage in male Fischer 344 rats. Rats were exposed to 0, 0.7, 2, 6, 10, or 15 ppm formaldehyde, 6 hours/day,... 

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