Noble, Robert

Gavin T. Noble, Robert J. Mart, Kwan Ping Liem, and Simon J. Webb ... 

Krebs, Robert E. The history and use of our earth s chemical elements a reference guide. Westport (CT) Greenwood P, 1998. ix, 346p. ISBN 0-313-30123-9 A short history of chemistry — Atomic structure The periodic table of the chemical elements — Alkali metals and alkali earth metals - Transition elements metals to nonmetals — Metallics and metalloids - Metalloids and nonmetals — Halogens and noble gases - Lanthanide series (rare-earth elements) — Actinide, transuranic, and transactinide series... 

We thank Drs. Richard A. Dixon, Gregory D. May, and Barbara Wolf-Sumner for critical review of the manuscript. The work in the authors laboratories were financially supported by The Samuel Roberts Noble Foundation. 

Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, Oklahoma 73401 ... 

Samuel Roberts Noble Foundation Ardmore, Oklahoma, USA... 

Acknowledgments We thank David Huhman for assistance with mass spectrometry analysis. This work was supported by the National Institutes of Health National Center for Complementary and Alternative Medicine (award 1 POl AT004511) and the Samuel Roberts Noble Foundation. 

Ryan R. P. Noble Elizabeth M. Grenik Robert M. Hough Meivyn J. Lintern David J. Gray Rob Hart, Peta Clode , John Murphy ... 

The discovery of vinblastine and vincristine is one of the most intriguing examples of serendipity in scientihc research in recent years. In 1952, the Canadian medical researcher Robert Laing Noble (1910-90) received a package from his brother. Dr. Clark Noble, containing 25 leaves from the Madagascar periwinkle plant. Vinca rosea. Clark had received the leaves from one of his patients in Jamaica, who said that natives on the island often used the plant to control their diabetes when insulin was not available. Clark, who was retired, suggested that his brother study the plant for possible use as a drug for the treatment of diabetes. 

When Robert Noble carried out his studies on the periwinkle leaves, he found that they had no effect on blood sugar levels. However, they did appear to signihcantly reduce a subject s white blood cell count. Perhaps, Dr. Noble reasoned, the product could be used to treat diseases characterized by abnormally high white blood cell counts, such as leukemia. He was successful in isolating two chemicals from the periwinkle leaves, which he named vinblastine and vincristine, that markedly decreased white blood cell counts in patients with certain forms of cancer. The two chemicals were the first anticancer agents derived from natural sources to be approved for use with human patients. 

Submitted by Paul Noble, Jr., and D. S. Tarbell.1 Checked by Willlam S. Johnson and Robert A. Kloss. 

Raymond P. Makikli.a Robert E. McMahon J. A. McRae Cal Y. Meyers Leonard E. Miller Robert Bruce Moffett Paul Noble, Jr. 

MSFACTs The Samuel Roberts Noble Foundation Metabolomics specttal formatting, alignment, and conversion tools (http //www.noble.org/PlantBio/Sumner/ msfacts /index.html)... 

Debra Rolison They were. Germany and other European countries are discussed in Noble s book.43 Robert Lichter Portugal actually was hostile. 

In the case of iron, and of other less noble metals, the reductive hydrodehalogena-tion of the substrates via metal dissolution has received much attention, especially for on-site remediation processes (e.g. reactive barriers). Although the dehalogena-tion is based on a corrosion process, rather than on an electrolytic process, the flourishing literature of the past few years prompted us to provide a selection of the bibliographic references (Boronina et al. 1995 Warren et al. 1995 Roberts et al. 1996 Farrell et al. 2000 Alonso et al. 2002 Kluyev et al. 2002 Dombek et al. 2004 Lowry and Johnson 2004 Mishra and Farrell 2005 Moglie et al. 2006 Laine et al. 2007). 

Water and other volatiles could have been supplied to Earth by comets and asteroids as part of the late veneer. The arguments for and against this hypothesis have recently been reviewed by Drake (2005). The D/H ratio measured in three comets to date is 2 x higher than on Earth, suggesting that comets could not have supplied more than 50% of Earth s water (Robert 2001). However, these comets may not be representative of objects colliding with the early Earth. If the Ar/H20 ratio measured in comet Hale-Bopp is typical, comets would have delivered 2 x 104 times more Ar than is presently found in Earth s atmosphere if they were the main source of Earth s water (Swindle Kring 2001). Consideration of the abundances of noble metals and noble gases led Dauphas Marty (2002) to estimate that comets contributed <1% of the Earth s water. It is unlikely that carbonaceous chondrites supplied most of the late veneer since these objects have different Os isotope ratios than Earth s mantle,... 

Comparisons of quantum-mechanical calculations of T-R transfer with experiment have been limited for the most part to H2, D2, and collisions of these molecules with themselves or with noble-gas atoms. Davison [59] compared his theoretical results on H2 with measurements by Rhodes [69] and Sluijter, Jonkman, Knaap, and Beenakker [70-73] compare their experimental values with the calculations of Takayanagi [55], Davison [57], and Roberts [74], Valley and Amme s experimental work [75] on the parahydrogen-noble-gas systems at room temperature was also compared with these theories. 

---