Nitrosamines tobacco induction

Substances carcinogenic to animals (polycyclic hydrocarbons and nicotine-derived N-nitrosamines) have been identified in tobacco smoke condensates from cigarettes, cigars and pipes. Polycyclic hydrocarbons are responsible for the hepatic enzyme induction that occurs in smokers. 

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Ciaravolo, S., G. Lionetti, F. Modestia, and A. Nunziata Speciation of chromium in mainstream and sidestream tobacco smoke using inductively coupled plasma optical emission spectroscopy Manuscript, May (2005). Ciaravolo, S., F. Modestia, and L. Nappi Analytical procedures for the determination of volatile nitrosamines in cigarette smoke 59th Tobacco Science Research Conference, Program Booklet and Abstracts, Vol. 59, Paper No. 43, 2005, p. 41. 

Hecht, S.S., A. Rivenson, J. Braley, J. DiBello, J.D. Adams, and D. Hoffmann Induction of oral cavity tumors in F344 rats by tobacco-specific nitrosamines and snuff Cancer Res. 46 (1986) 4162-4166. 

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