2-Nitropropane health effects

Chronic health effects in humans from exposure to 2-nitropropane have not been adequately determined, although a retrospective mortality smdy of 1481 employees and former employees of a 2-nitropropane production facility with up to 27 years of exposure found no increase in cancer of the liver or other organs and no unusual disease mortality pattern. ... 

Toxicity and health effects Laboratory rats exposed to 2-nitropropane in high concentrations (207 ppm) developed adverse liver changes like hepatocellular hypertrophy, hyperplasia, necrosis, and liver carcinoma. It has been reported that prolonged exposure to concentrations of 20-45 ppm of 2-nitropropane caused nausea, vomiting, diarrhea, anorexia, and severe headaches among workers. Industrial workers handling 2-nitropropane for the application of epoxy resins to the walls of a nuclear power plant developed toxic hepatitis. - ... 

An employee health examination including workers exposed to personal time-weighted average levels below 25 ppm [91 mg/m ] 2-nitropropane revealed no adverse effects in the lung, liver, kidney, skin or haematopoietic and cardiovascular systems (Crawford et al., 1985). 

U.S. Environmental Protection Agency. 1985. Health and environmental effects profile for 2-nitropropane. EPA /600/x-85/112. Cincinnati, OH Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development. 

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