Nitrophenylarsonic Acid

P-NO2C6H4As03hJa2 H NaBF4 T N2 H2O F-N02CfiH4As03Na2 + 2HC1 F-N02CaH4As03H2 - - 2NaCl 

Submitted by A. Wayne Ruddy and Edgah B. Starkey, Checked by Cufe S. HAiflLTON and Richard E. Benson. 

In a 2-1. beaker provided with an efficient mechanical stirrer, 52 g. (0.4 mole) of sodium metaarsenite and 16 g. (0,4 mole) of 

The sodium arsenite solution may also be prepared by dissolving 39.6 g. (0.2 mole) of arsenious oxide and 32 g. (0.8 mole) of sodium hydroxide in 600 ml. of water. 

Accoidiiig to the submitters -nitrobenzenediazonium borofluoride may also be prepared as follows  

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Arsonic and arsinic acids have found a number of industrial uses. They have been used as corrosion inhibitors for iron and steel, additives to motor fuel, agricultural bactericides, herbicides, and fungicides. 3-Nitro-4-hydroxyphenylarsonic acid (roxarsone) [121 -19-7] C H AsNOg, has found widespread use as an additive to poultry feed for the control of coccidiosis and other poultry diseases (122,123). Arsanilic acid [98-50-0] C HgAsNO, has also been used for this purpose (124) and for growth promotion in swine. It is manufactured and suppHed by Duphar Nutrition Co., Inc., Fleming Laboratories, Inc., Dr. Mayfield Laboratories, Inc., and Whitmoyer Laboratories, Inc. 4-Nitrophenylarsonic acid [98-72-6] C H AsNO and... 

Bromo-4-nitrophenylarsonic acid 2-Bromo-6-nitrophenylarsonic acid... 

Chloro-4-nitrophenylarsonic acid 3-Nitro-4-chlorophenylarsonic acid... 

Mohri T, Hisanaga A, Ishinishi N (1990) Arsenic intake and excretion by Japanese adults a 7-day duplicate diet study. Food Chem Toxicol 28 521-529 Moody JP, Williams RT (1964a) The fate of 4-nitrophenylarsonic acid in hens. Food Cosmet Toxicol 2 695-706... 

A comparative study of several established histomonastats including 4-nitrophenylarsonic acid, p-ureidobenzenearsonic acid, 3,5-dinitrosali-cylic acid-5-nitrofurfurylidene hydrazideO and dimetridazole was published. 53 The 5-nitroimidazoles ronidazolese and ipronidazoless-ei are superior new histomonastats. 

Organic arsenicals such as arsenilic acid, 3-nitro-4-hydroxyphenylarsonic acid, 4-nitrophenylarsonic acid, and p-ureidobenzenearsonic acid have been used as a feed additive since the 1950 s [4]. The U.S. Food and Administration approves of all four of these compounds for use in poultry and swine feeds but only at levels low enough to preclude residues in edible animal tissues which would be hazardous to human health [10]. In France and other countries almost all uses of these compounds are forbidden. 

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