Nitroglycerine Subject

Whilst carbon monoxide and nitrogen oxides are the toxic products of explosives, other constituents of the fume cause a characteristic smell. As the nitroglycerine content of explosives is reduced, this smell tends to become rather unpleasant. Subjective tests must be used for its estimation. 

Subjective measures of drug response include the number of painful episodes, amount of rapid-acting nitroglycerin consumed, and patient-reported alterations in activities of daily living (e.g., time to walk two blocks, number of stairs climbed without pain). 

For rolling the dough should contain a relatively small amount of solvent (should be dry ) otherwise it adheres to the surface of the rolls and is then difficult to remove. On an average, dough to be rolled should contain less solvent (about 50%) than that subjected to pressing. Rolls especially adapted for the manufacture of nitroglycerine powder are most widely used, but not heated. 

Most nitric esters are subjected to heating at 120-132°C. In the case of nitroglycerine and nitroglycerine-like explosives, and also of nitrostarch, a temperature of 110-120°C is used. 

After being washed with carbonate, nitroglycerine is subjected to a final washing with water at first with hot water at 50-70°C and finally with cold water, in order to remove the sodium carbonate completely. Frequently the washing operations are shortened to 5 min except for the sodium carbonate wash, which lasts each 15 min. 

A sample of the washed nitroglycerine is subjected to a heat-test. After removing sodium carbonate to max. 0.04%, nitroglycerine should give a positive test for 20 min at 80°C. 

Stabilized nitroglycerine in the form of an aqueous emulsion flows into storage tank (1). If every batch of nitroglycerine is subjected to heat-test two storage tanks should be provided. 

Sublingual Rapid onset not subject to first-pass inactivation Drug must be easily absorbed from oral mucosa Nitroglycerin... 

When ignited or subjected to sudden impact, nitroglycerin decomposes very rapidly and exothermically ... 

When confined in the dosed cell and subjected to the isothermal storage test performed at a T, above 55 °C, however, 1.5 cm of nitroglycerin, the mass of which is about 2.4 g, behaves as a chemical of the AC type in such a manner as to start the autocatalytic reaction a long time after the start of the isothcmral storage test in accordance with Eq. (59). This manner is the same as that shown in Fig. 6 presented in Section 3.1,... 

When confined in the closed cell and subjected to the isothermal storage test performed at a 7) of 61.11 T), 1.5 cm of nitroglycerin started the autocatalytic reaction about 17,5 h after the start of the isothermal storage test. The sample was found to be pale yellow and gave off the odor of nitrogen dioxide after the test the inside of the cell was found to be pressurized besides. 

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