Nitroglycerine pharmacokinetics

Nitrogen tribromide, 4 319 Nitrogen trifluoride, 22 830 production of, 22 845 Nitroglycerin[e] (NG), 9 47, 48 10 730 molecular formula and structure, 5 110t pharmacokinetics, 5 115 processes, 27 164 production of, 27 174 Nitro group, 27 157-158 Nitroguanidine, 20 734 Nitrol, molecular formula and structure, 5 1 lOt... 

Shaw, J.E. (1984) Pharmacokinetics of nitroglycerin and clonidine delivered by the transdermal route. American Heart Journal, 108, 217-222. 

JX Sun, AJ Piraino, JM Morgan, JC Joshi, A Cipriano, K Chan, E Redalieu. Comparative pharmacokinetics and bioavailability of nitroglycerine and its metabolites from Transderm-Nitro, Nitodisc, and Nitro-Dur II systems using a stable-isotope technique. J Clin Pharmacol 35 390—397, 1995. 

Kwon HR, Green P, Curry SH. Pharmacokinetics of nitroglycerin and its metabolites after administration of sustained-release tablets. Biopharm Drug Dispos 1992 13 141-152. 

A. Classification and Pharmacokinetics Nitroglycerin (the active ingredient in dynamite) is the most important of the nitrates and is available in forms that provide a range of durations of action from 10-20 minutes (sublingual) to 8-10 hours (transdernial) (Table 12-2). Because treatment of acute attacks and prevention of attacks are both important aspects of therapy, the pharmacokinetics of these different dosage forms are clinically significant. 

Other nitrates are similar to nitroglycerin in their pharmacokinetics and pharmacodynamics. Isosorbide dinitrate is another commonly used nitrate it is available in sublingual and oral forms. Isosorbide dinitrate is rapidly denitrated in tbe liver to isosorbide mononitrate, which is also active. Isosorbide mononitrate is available as a separate drug for oral use. Several other nitrates are available for oral use and, like the oral nitroglycerin preparation, have an intermediate duration of action (4-6 hours). Amyl nitrite is a volatile and rapidly acting vasodilator that was used for angina by the inhalational route but is now rarely prescribed. 

Fung HL. Pharmacokinetics of nitroglycerin and long-acting nitrate esters. Am J Med 1983 72(Suppl) 13-19. 

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