Nitrogen nucleophiles, reactions with naphthyridines

It is not surprising that the behavior of naphthyridines toward nucleophiles has been a subject of numerous studies1 8 and that nucleophilic substitution in naphthyridines has become a very valuable and efficient method to synthesize substituted naphthyridines. In the last decade many important and new features of nucleophilic substitution in naphthyridines using nitrogen nucleophiles (especially liquid ammonia and potassium amide/liquid ammonia) have been found. In view of these recent results it seems worthwhile to review this area of research. The present chapter is concerned with the reactions of naphthyridine with nitrogen nucleophiles for a full review of naphthyridine chemistry, see the chapter by Paudler and Sheets, p. 147 of this volume. 

For a detailed account of naphthyridine reactions with nitrogen nucleophiles, see chapter by van der Plas et al., p. 95 of this volume. 

The chemistry and physical properties of 1,7-naphthyridines (3) <82H(19)363> and of heterocycles (l)-(6) <83AHC(33)147) have been reviewed. The reactions of heterocycles (l)-(6) with nitrogen nucleophiles have also been reviewed <83AHC(33)95>. Reviews covering pyranopyridines (87AKZ104) and pyranopyrans <75MI 715-01) have been published. 

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