Nitroarginine methyl ester

Most NOS inhibitors are stmcturaHy related to L-arginine and do not differentiate between the isoforms (Table 15). t - / 7-Methy1 arginine (l-NMA) (264) is a competitive inhibitor and also irreversibly inhibits NOS. T.-/ 7-Nitroarginine (l-NNA) (265), L-AP -nitroarginine methyl ester (t.-NAMF) (266),... 

NADPH Reduced nicotinamide adenine dinucleotide phosphate NAF Neutrophil activating factor l-NAME L-Nitroarginine methyl ester... 

Sawyer, T.W. (1998a). Characterization of the protective effects of L-nitroarginine methyl ester (L-NAME) against the toxicity of sulphur mustard in vitro. Toxicology 131 21-32. 

As might be anticipated from the dependency of CBF on intracellular cAMP, -agonists elevate CBF, although the concentrations required to do this are greater than those required for bronchodilatation (Pavia etal., 1984). Evidence from primary cultures of bovine bronchial epithelium has been presented which su ests that a component of the isoprenaline-stimulated increase in CBF is dependent up)on the formation of nitric oxide (NO Jain eteU., 1993). The nitric oxide synthase (NOS) inhibitors L-nitromonomethyl arginine (L-NMMA) and L-nitroarginine methyl ester (L-NAME) both reduced... 

L-NAME (L-A/ -nitro-L-arginine methyl ester Af -nitro-t-arglnine methyl ester nitroarginine methyl ester) is a NITRIC OXIDE SYNTHASE INHIBITOR, extensively used as a pharmacological tool. l>NI 7-nitroindazole. 

L-AP>nitroarginine methyl ester l-NAME. iV -nitro-L-arginine methyl ester l-NAME. nitrofural nitrofiirazone. nitrofurantoin (ban. inn] (Furadantln " Macrobid ... 

Furthermore, the new methodology for NO measurement was also found to be an effective assay using tissues from rabbit and porcine trachea epithelium in the presence of ATP and a specific inhibitor of nitric oxide synthase (NOS), l-NG-nitroarginine methyl ester hydrochloride (l-NAME) (Figure 10.16). The measured... 

Several synthetic methods for the reduction of a-amino esters have also been reported. The reduction of methyl or ethyl esters by diisobutylaluminum hydride (DIBAL-H) at low temperature (—78 °C) has been described as useful for the preparation of a-amino aldehydes. 1118 20 Again, this method suffers from overreduction. Reductive methods involving mild reductive agents have been described. The reduction of phenyl esters 6 21 (readily prepared from the corresponding amino acid 5) with lithium tri-ferf-butoxyaluminum hydride is efficient for the preparation of various Boc-a-amino aldehydes including Na-Boc-7V J-nitroargininal and A7a-Boc-W"-Z-argininal (Scheme 5). 

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