Neutrophil-activating factor

NADPH Reduced nicotinamide adenine dinucleotide phosphate NAF Neutrophil activating factor l-NAME L-Nitroarginine methyl ester... 

Walz A, Peveri P, Aschauer H, Baggiolini M. Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes. Biochem Biophys Res Commun 1987 149 755-761. 

The generation and recognition of neutrophil-activating factors Structure and function of neutrophil receptors... 

The major neutrophil-activating factors within rheumatoid joints are immune complexes. These predominantly IgG-containing complexes vary considerably in size. Curiously, blood neutrophils do not generate reactive oxidants in response to soluble immune complexes, needing to be primed before they can be activated in this way (Fig. 8.4). It is therefore of interest to note that neutrophils isolated from the synovial fluid of patients with rheumatoid arthritis have been primed in vivo and can secrete substantial quantities of reactive oxidants in response to these soluble complexes. Thus, it is extremely likely that these soluble immune complexes are responsible for activation of the secretion of reactive oxygen metabolites by infiltrating synovial-fluid neutrophils. This phenomenon may contribute to the events that lead to the destructive joint processes characteristic of this disease. 

Colditz, I., Zwahlen, R., Dewald, B., and Baggiolini, M. (1989) In vivo inflammatory activity of neutrophil-activating factor, a novel chemotactic peptide derived from human monocytes. Am. J. Pathol. 134, 755-760. 

I. Colditz, R. Zwahlen, B. Dewald, and M. Baggiolini, In Vivo Inflammatory Activity of Neutrophil-Activating Factor by Monomeric lnterleukin-8. American Journal of Pathology. 134 (1989) 755-760. 

P. Peveri, A. Walz, B. Dewald. and M. Baggiolini, A Novel Neutrophil-Activating Factor Produced by Human Mononuclear Phagocytes, Journal of Experimental Medicine. 167 (1988) 1547-1559. 

IL-8 Neutrophil-activating factor (NAF) Monocytes Neutrophils chemotaxis granular exocytosis respiratory burst... 

Bindley, I., Aschauer, H., Seifert, J. M., Lam, C., Bmnowsky, W., Kownatzki, E., et al. (1988). Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor Biological equivalence between natural and recombinant neutrophU-activating factor. Proceedings of the National Academy of Sciences of the United States of America, 85, 9199-9203. 

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