Nitroalkenes tandem

Compared to the cycloadditions of nitroalkenes, tandem cycloadditions of 1,3,4-oxadiazoles consist not of two, but of three elementary reactions. In the first step, a 1,3,4-oxadiazole 428 serves as an electron-poor heterodiene (4jt-component) and reacts thermally with an alkene dienophile (2jt-componait) by a [4-1-2] cycloaddition reaction. The preferred dienophile is electron-rich, unhindered, and strained. At the elevated temperatures required for the first step [169], the immediate product of this reaction, 430, is unstable and undergoes extrusion of dinitrogen by a [3 + 2] cycloreversion to form dipole 431 [170]. At the high temperatures required for its formation, 431 cannot be directly observed either and reacts by a [3 + 2] cycloaddition with an available dipolarophUe, which can be the same 27i-component that served as the dienophile or something else. Because none of the intermediates is isolated and no change in reaction conditions is required, tandem [4-f 2]/[3- -2] cycloadditions of 1,3,4-oxadiazoles are tandem cascade processes as defined earlier in this chapter. 

Thepreparadonof resin-bound nitroalkenes via a micro wave-assisted Knoevenagel reacdon of resin-bound nitroacedc acid v/ith aryl and alkyl subsdnited Mdehydes is reported. The potendiil of these resin-bound nitroalkenes for apphcadon in combmatorlM chemistry is demonstratedby a Diels-Alder reacdon v/ith 2,3-dimethylbutadienefScheme 8 9) Iris Mso used for one-pot three-component tandem [4t-2 /[3t-2 reacdons v/ith ethyl vinyl ether and styrene... 

One-pot tandem reactions, starting v/ith nitroalkenes and allyl alcohols leading to fitnaion-alized tetrahydrofitrans, have been repotted fEq. 8.87. ... 

Hetero Diels-Alder reacdons using nitroalkenes followed by 1,3-dipolar cycloaddidons provide a nsefid strategy for the constnicdon of polycychc heterocycles, which are found in naturM products. Denmark has coined the term tandem [4t-2 /[3t-2 cycloaddidon of nitroalkenes for this type of reacdon. The tandem [4-i-2 /[3-i-2 cycloaddidon can be classified into font famihes as shown in Scheme 8.31, where A and D mean an electron acceptor and electron donor, respecdvely. " In generril, electron-rich alkenes are favored as dienophdes in [4-i-2 cycloaddidons, whereas electron-deficient alkenes are preferred as dipolarophdes in [3-i-2 cycloaddidons. 

Sinnlarly, f-i- -casuralme, a pentahydroxy pyrrolizidine alkaloid, is prepared by a tandem [4-i-3 /[3-i-3 cycloadchdon involving nitroalkene, chiral vinyl ether, and vinyl silane This process creates five of the six stereocenters present in this potent glycosidase inhibitor fScheme 8 35 ... 

Intra [4+2]/inter [3+2] This type of tandem reaction nsmg nitroalkenes has n been extensively explored, and one example has been reported fEq 8 111 ... 

Inter [4+2]/intra [3+2] This typeof tandem reaction nsmg nitroalkenes hasbeen expbred most extensively Four subfamilies of tandem cycloaddiQon exist, which anse from the font different pomts of attachment of the dipolarophihc tether They are defined as fused, spiro, and bridged modes, as depicted m Scheme 8 37... 

When Talkoxy-l,4-pentadienes are used Instead of 2-alkoxy-l,4-pentadienes, tandem Inter [4- 2 /lntra [3- 2 cycloaddidon of nitroalkenes followed by hydrogenolysls affords a versatile asymmetric synthesis of highly fiincdonalized aminocyclopentanes fScheme 8.47i. ... 

The tandem Michael and cyclopropanation reaction of lithium enolates with nitroalkenes gives tricyclic ketones in one pot, as shown in Eq. 7.42.43... 

The preparation of resin-bound nitroalkenes via a microwave-assisted Knoevenagel reaction of resin-bound nitroacetic acid with aryl and alkyl substituted aldehydes is reported. The potential of these resin-bound nitroalkenes for application in combinatorial chemistry is demonstrated by a Diels-Alder reaction with 2,3-dimethylbutadiene (Scheme 8.9). It is also used for one-pot three-component tandem [4+2]/[3+2] reactions with ethyl vinyl ether and styrene 46... 

Hassner and coworkers have developed a one-pot tandem consecutive 1,4-addition intramolecular cycloaddition strategy for the construction of five- and six-membered heterocycles and carbocycles. Because nitroalkenes are good Michael acceptors for carbon, sulfur, oxygen, and nitrogen nucleophiles (see Section 4.1 on the Michael reaction), subsequent intramolecular silyl nitronate cycloaddition (ISOC) or intramolecular nitrile oxide cycloaddition (INOC) provides one-pot synthesis of fused isoxazolines (Scheme 8.26). The ISOC route is generally better than INOC route regarding stereoselectivity and generality. 

Scheme 8.27 presents a highly stereoselective one-pot tandem 1,4-addition-ISOC for the construction of functionalized carbocycles. Addition of Grignard reagents to nitroalkenes and subsequent ISOC are carried out in one pot. The advantages of ISOC over INOC, namely, greater stereoselectivity and adaptability to one-pot conditions, have been demonstrated in Scheme 8.27.138... 

Recently, Denmark and coworkers have developed a new strategy for the construction of complex molecules using tandem [4+2]/[3+2]cycloaddition of nitroalkenes.149 In the review by Denmark, the definition of tandem reaction is described and tandem cascade cycloadditions, tandem consecutive cycloadditions, and tandem sequential cycloadditions are also defined. The use of nitroalkenes as heterodienes leads to the development of a general, high-yielding, and stereoselective method for the synthesis of cyclic nitronates (see Section 5.2). These dipoles undergo 1,3-dipolar cycloadditions. However, synthetic applications of this process are rare in contrast to the functionally equivalent cycloadditions of nitrile oxides. This is due to the lack of general methods for the preparation of nitronates and their instability. Thus, as illustrated in Scheme 8.29, the potential for a tandem process is formulated in the combination of [4+2] cycloaddition of a donor dienophile with [3+2]cycload-... 

The strategy based on tandem cycloaddition leads to a short and efficient asymmetric synthesis of the pyrrolizidine necine base (-)-hastanecine, as shown in Scheme 8.32.163 Pyrrolizidine alkaloids have a long history for attracting the interest of synthetic chemists because of their physiological properties. The method of Denmark shown in this scheme is very simple and applied to synthesis of various alkaloids. The Lewis acid-promoted [4+2] cycloaddition between 2-acyloxy nitroalkene and chiral vinyl ether gives a nitronate that... 

Asymmetric tandem cycloaddition of a chiral carbohydrate nitroalkene with ethyl vinyl ether in the presence of electron-withdrawing alkenes produces a facile assembly of bicyclic systems, which can further be selectively cleaved to give homologated carbohydrates (Eq. 8.110).176... 

Di- and trisubstituted nitroalkenes tethered to dipolarophiles (unsaturated esters, nitriles) undergo tandem [4+2]/[3+2] cycloadditions with 2,3-dimethyl-2-butene or butyl vinyl ether in the presence of Lewis acids (Eq. 8.112). For the dimethylene tether, the E-configuration of the dipolarophile is preferred, and the products arise selectively from a syn-endo pathway.177... 

The extremely high selectivity for tandem cycloaddition, the ease of manipulation of the nitroso acetals, and the release of the vinyl ether appendage in the hydrogenolytic cleavage constitute ideal features for asymmetric modifications of the cycloadditions with chiral vinyl ethers. As discussed in Section 8.3.2.1 (Inter [4+2]/inter [3+2] cycloadditions of nitroalkenes), the stereochemical course depends on the Lewis acids. The results are summarized in Scheme 8.38.179 The high levels and complementary selectivity with three chiral vinyl ethers and two kinds of Lewis acids (Ti- and Al-based Lewis acids) are presented in this scheme. 

The tandem [4+2]/[3+2] cycloaddition of nitroalkenes is an extremely flexible method for the synthesis of necins. All of the stereochemical attributes are subject to a high level of... 

The synthesis of (+)-crotanecine is accomplished in 10 steps in a 10.2% overall yield, as shown in Scheme 8.42. The key step in the asymmetric synthesis is a Lewis acid-promoted, tandem inter [4+2]/intra [3+2] cycloaddition between a (fumaroyloxy)nitroalkene and chiral [J-silylvinyl ether, in which the substituted silanes are used as hydroxy synthons.181... 

When a-tethered nitroalkenes bearing three or four methylene chains and ester-activated dipolarophiles react with vinyl ethers, spiro mode tandem cycloaddition takes place to give tricyclic spiro nitroso acetals in good yield and high diastereoselectivity (Scheme 8.46).184... 

In recent years, the importance of aliphatic nitro compounds has greatly increased, due to the discovery of new selective transformations. These topics are discussed in the following chapters Stereoselective Henry reaction (chapter 3.3), Asymmetric Micheal additions (chapter 4.4), use of nitroalkenes as heterodienes in tandem [4+2]/[3+2] cycloadditions (chapter 8) and radical denitration (chapter 7.2). These reactions discovered in recent years constitute important tools in organic synthesis. They are discussed in more detail than the conventional reactions such as the Nef reaction, reduction to amines, synthesis of nitro sugars, alkylation and acylation (chapter 5). Concerning aromatic nitro chemistry, the preparation of substituted aromatic compounds via the SNAr reaction and nucleophilic aromatic substitution of hydrogen (VNS) are discussed (chapter 9). Preparation of heterocycles such as indoles, are covered (chapter 10). 

The reaction presented in Scheme 3.38 is involved in the novel [4+ 2] [3+ 2] tandem strategy for the use of nitroalkenes (42) in target organic synthesis (for details, see Section 3.4.4). Taking into account the great contribution of Prof. S. Denmark the in investigation of different aspects of this strategy, the latter can be classified as Denmark s approach. The principal aspects of [4+ 2]-cyclo-addition of nitro olefins were summarized in two fine reviews (99, 100). 

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