Nitro aromatic

A number of selected aromatic nitro compounds are collected in Table IV,16A, It will be noted that a few nitro aromatic esters have been included in the Table. These are given here because the nitro group may be the first functional group to be identified aromatic nitro esters should be treated as other esters and hydrolysed for final identification. 

POTASSIUM SALTS OF NITRO-AROMATIC DERIVATIVES, explosive 0158 ... 

Aromatic fluorodenitration was first discovered in the reaction of polychloro-nitrobenzenes with potassium fluoride, when 2,3,5,6-tetrachlorofluorobenzene was prepared in 37% yield from 2,3,5,6-tetrachloronitrobenzene 105] The technique has been adapted to prepare aryl fluorides from other activated nitro aromatics for applications in pharmaceutical and polymer chemistry (equation 31) Fluorodenitration also has been applied to prepare radiolabeled ( F) fluo-roaromatics [74, 106]... 

Dimethylformamide is also a good solvent for PETN. According to Lang (Ref 15a) at 40°C lOOg of sotn contain 40g PETN at 60°C lOOg of soln contain 50g PETN at 100°C lOOg of soln contain 70g PETN PETN forms eutectics with a number of liq or molten nitro-aromatic compds. The compns and melting points of some of these as reported by Urbanski (Ref 4) are ... 

Nitro-aromat Azoxy-aromat Bis-[2-methoxy-athyl]-ather 475... 

The Separation of a Mixture of Aromatic and Nitro-Aromatic Hydrocarbons... 

Nishioka MG, CC Howard, DA Conros, LM Ball (1988) Detection of hydroxylated nitro aromatic and hydroxy-lated nitro polycyclic aromatic compounds in ambient air particulate extract using bioassay-directed fractionation. Environ Sci Technol 22 908-915. 

Nitro aromatics owe their great importance in organic synthesis for being intermediates for the generation of the respective anilines by hydrogenation [17, 61]. For instance, pharmaceuticals are produced via that route [61],... 

Sulphonation of nitro-aromatic compound Ciba-Geigy Stoessel (1994)... 

Kulkarni, M. and Chaudhari, A., Microbial remediation of nitro-aromatic compounds An overview, J. Environ. Manage., 85, 496-512, 2007. 

See Other NITRO AROMATIC- ALKALI HAZARDS See Other NITRO ARYL COMPOUNDS... 

Monocyclic nitro aromatics such as m-dinitrobenzene and its derivatives also react with ethyl isocyanoacetate to give the corresponding isoindoles (Eq. 10.40).44... 

Similar to the Fisher indole synthesis, reductive cyclization of nitro aromatics offers a powerful means of forming indoles. Reductive cyclization of ortho, 2 -dinitrostyrenes has occurred in many ways, by TiCl3, NaBH4-Pd/C, H2-Pcl/C, and other reductive methods.89 Corey and coworkers have used the Borchardt modification (Fe-AcOFI, sihca gel, toluene at reflux for the reductive cyclization of o-ji-dinitrostyrenes) to prepare 6,7-dimethoxyindole (Eq. 10.65) in a total synthesis of aspidophytine (see Schemes 3.3 and 3.4 in Section 3.2.l).89d... 

While the cytochrome P-450 monooxygenase reaction described in Eq. (1) often involves hydroxylation of carbon, many other reactions are catalyzed by these enzyme systems. These reactions include oxidation of nitrogen and sulfur, epoxidation, dehalogenation, oxidative deamination and desulfuration, oxidative N-, O-, and S-dealkylation, and peroxidative reactions (56). Under anaerobic conditions, the enzyme system will also catalyze reduction of azo, nitro, N-oxide, and epoxide functional groups, and these reductive reactions have been recently reviewed (56, 57). Furthermore, the NADPH-cytochrome P-450 reductase is capable of catalyzing reduction of quinones, quinonimines, nitro-aromatics, azoaromatics, bipyridyliums, and tetrazoliums (58). 

First industrial attempts (a) Reduction nitro aromatics, unsat. 

An elegant example of a paired mediated reaction has been reported by Chaussard and Lahitte [69] EDF (Electricite de France), who use Cr(VI) generated at the anode of a divided cell to oxidize the methyl side chain of a nitro-aromatic and Ti(III) generated at the cathode to reduce the nitro group. The reduction step, due to the faster homogeneous rate can be performed within the cell, whereas the oxidation has to be performed in a stirred tank reactor. 

In this case history, the control of the TMRaa (adiabatic Time-to-Maximum-Rate) is to be achieved in a semi-continuous reactor process by the dynamic optimization of the feed rate. Here it is desired to have the highest possible space-time-yield STY and it is necessary to achieve a thermally safe process (Keller, 1998). The reaction involves the addition of a sulfur trioxide on a nitro-aromatic compound... 

Drugs, environmental samples, ketones, nitro-aromatics... 

The electronic effect of the substituents on nitro-aromatics is rationalized by the Yukawa-Tsuno equation. 

VI. NON-COVALENT INTERACTIONS BETWEEN AMINES AND NITRO AROMATIC DERIVATIVES... 

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